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Pharmac > Ergot Alkaloids, Prostanoids and Uterotonics > Flashcards

Ergot Alkaloids, Prostanoids and Uterotonics Flashcards

1
Q

Ergot alkaloids are produced by the fungus

A

Claviceps purpura

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2
Q

Examples of ergot alkaloids

A

Bromocryptin
Ergomovine
Ergotamine
Lysergic acid diethylamine
Methysergid

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3
Q

The manifestations of EA poisoning (ergotism)

A

Hallucination
Prolonged vasospasm
Stimulation of uterine muscle

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4
Q

There are two major families of ergot alkaloids

A

Amine alkaloids
Peptide alkaloids

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5
Q

Types of amine alkaloids

A

Ergomovine
LSD

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6
Q

The example of peptide alkaloid

A

Ergotamine
Bromocryptin

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7
Q

Clinical uses of EA

A

Used in treatment of hyperprolactinaemia

Used in treating migraines

Used in treating postpartum hemorrhage

Suppression of physiologic lactation

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8
Q

Use of PGE1

A

Smooth muscle relaxing effect to maintain patent ductus arteriosus in neonates awaiting heart surgery

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9
Q

Example of a PGE1 analogue

A

Misoprostol

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10
Q

Example of a PGE2

A

Dinoprostone

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11
Q

Alpha PGF2 is used in treating

A

Open angle glaucoma

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12
Q

Example of PGF2 is

A

Latanoprost

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13
Q

PGE2, PGE1 and PGF2 are used for what in obstetrics

A

Induce pregnancy

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14
Q

Pharmacologic agents that function in uterine contraction

A

Misoprostol
Oxytocin
Ergomovine

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15
Q

What is the MOA of Misoprostol

A

Increases Intracellular Ca2+ levels to cause uterine contraction

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16
Q

Clinical uses of Misoprostol

A

Induction of labour
Induction of miscarriage
Treatment of postpartum hemorrhage
Treatment of PUD

17
Q

Where’s oxytocin produced

A

Paraventricula nuclei of hypothalamus

18
Q

MOA of oxytocin

A

Acts via G-protein coupled receptors to cause uterine contraction by increasing Intracellular calcium levels

19
Q

A uterotonic not used to induce or augment labour

A

Ergomovine/Ergometrin

20
Q

What is the side effects of most Uterotonics

A

Uterine rupture
Hyperstimulation

21
Q

What are tocolytics

A

These are drugs used to cause relaxation of the uterus

22
Q

Examples of tocolytics

A

Calcium channel blocker: Nifedipine
Oxytocin receptor inhibitors: Atosiban
Beta adrenergic agonists: Salbutamol

Pharmac (27 decks)

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