Endocrine Physiology Costanzo notes Flashcards Preview

Endo/Repro Midterm > Endocrine Physiology Costanzo notes > Flashcards

Flashcards in Endocrine Physiology Costanzo notes Deck (74)
Loading flashcards...
1

classic endocrine glands

hypothalamus
anterior and posterior lobes of the pituitary
thyroid
parathyroid
adrenal cortex
adrenal medulla
gonads
placenta
pancreas

2

the signal peptide of a hormone is removed in the _____, converting the preprohomrone to a prohormone

signal peptide cleaved in the ER

3

prohormones are packaged into secretory vesicles in the ______ _____ where they are cleaved by proteolytic enzymes to produce the final hormone
glycosylation and phosphorylation also occur here in this organelle

golgi apparatus

4

the adrenal cortex, gonads, corpus luteum and placental all secrete what type of hormone

steroid hormones

5

all steroid hormones are derivatives of what molecule

cholesterol

6

catecholamines are examples of what kind of hormones

amine hormones

7

the amine hormones include:

epinephrine
norepinephrine
dopamine

8

amine hormones are derivatives of what AA

tyrosine

9

feedback loop in which the hormone feeds back to the hypothalamic pituitary axis

long-loop feedback

10

feedback loop where anterior pituitary hormone feeds back to the hypothalamus to prohibit the secretion of the hypothalamic releasing hormone

short loop feedback

11

feedback loop where the hypothalamic hormone inhibits its own secretion

ultra-short loop feedback

12

ways to change the responsiveness of a tissue to a hormone

number of receptors
affinity of receptors

13

hormone concentration that produces 50% of maximal response

sensitivity

14

describe the function of GRFs

guanosine nucleotide releasing factors
dissociate GDP so GTP can bind

ACTIVATE

15

describe the function of GAPs

GTPase activating factors
facilitate hydrolysis of GTP

INHIBIT

16

hormones that utilize tyrosine kinase mechanisms for their MoA

insulin
IGF-1
growth hormone
prolactin

17

hormones that utilize adenylate cyclase for their MoA

ACTH
LH
FSH
TSH
ADH
HCG
MSH
CRH
Calcitonin
PTH
glucagon

18

hormones that utilize pohosphlipase C for their MoA

GnRH
TRH
GHRH
Angiotensin II
ADH
Oxytocin
Alpha1 recpetor

19

steroid hormones that pass the plasma membrane include

glucocorticoids
estrogen
progesterone
testosterone
Aldosterone
vitD

20

cGMP utilizing hormones

ANP
NO

21

G protein associated with phospholipase C

Gq protein

22

phospholipase c mechanisms induce what ion increase in the cell .

Ca

23

in monomoeric type RTKs, binding of ligand to EC domain results in _______ of the receptor, activating ______ tyrosine kinase, and phosphorylation of what

results in dimerization of the receptor
activation of intrinsic tyrosine kinase
phosphorylation of tyrosine on itself and otherp toeins

NGF and EGF

24

steroid receptor proteins are located hwere in a cell

in the cytosol or nucleus

25

the c domain among steroid hormone receptors has what binding ability

two zinc fingers responsible for DNA binding

26

zinc fingers bind to what DNA elements

steroid responsive elements
SREs

27

hormone-hormone receptor complexes have the ability to do what

regulate the rate of transcription

28

the posterior lobe of the pituitary is derived from what kind of tissue

neural tissue
neurohypophysis

29

secretory products of the posterior pituitary

ADH
Oxytocin

30

As ADH and oxytocin are secreted by nerve axons located in the posterior pituitary, they are considered what type of molecule

neuropeptides