Endocrine System Flashcards

1
Q

What 5 things are endocrine glands involved in?

A
  1. Regulating cell metabolism.
  2. Maintenance of homeostasis.
  3. Sexual development and reproduction.
  4. Growth and development from child to adult.
  5. Modulating long term behaviour.
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2
Q

What are the three types of hormones?

A
  1. Protein (usually injected)
  2. Steroid (synthesised form cholesterol, oral administration).
  3. Amino acid derivatives (thyroid hormones and catecholamines).
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3
Q

How are steroid and thyroid hormones transported?

A
  1. Via specific carrier proteins.
  2. To improve solubility.
  3. Increases half life.
  4. Provides a reserve in the blood.
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4
Q

What hormones can bind to intracellular receptors in nucleus?

A
  1. Steroid hormones.

2. Thyroid hormones.

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5
Q

What is an example of an endocrine axes/cascades?

A

Hypothalamo-hypophyseal-gonadal axis.

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6
Q

What does the final product of a cascade do?

A

Inhibits a hormone higher up in cascade, usually in the hypothalamus as it is very involved in negative feedback.

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7
Q

What does anterior pituitary gland develop from?

A

Epithelium of mouth.

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8
Q

What essentially is the anterior pituitary gland?

A

Down growth from the hypothalamus.

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9
Q

What are the two endocrine functions of the hypothalamus?

A
  1. Controls release of hormones from anterior pituitary gland by releasing hormones.
  2. Secretes hormones that are stored in the posterior pituitary gland.
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10
Q

What is the anterior pituitary gland called and what is it made from?

A

Adenohypophysis, consists of epithelial tissue.

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11
Q

What does anterior pituitary gland secrete?

A
  1. GH.
  2. TSH.
  3. ACTH.
  4. FSH.
  5. LH.
  6. Prolactin.
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12
Q

What is the posterior pituitary gland called and what is it made from?

A

Neurohypophysis, consists of neural tissue.

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13
Q

What cells secrete hormones which are stored by the posterior pituitary gland?

A

Neurosecretory cells.

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14
Q

What does the posterior pituitary gland secrete?

A
  1. ADH.

2. Oxytocin.

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15
Q

How do thyroid glands develop?

A

Down growth of epithelia of tongue.

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16
Q

What do follicular cells secrete?

A

T3 and T4.

17
Q

What are T3 and T4 stored as?

A

Thyroglobin in the colloid.

18
Q

Function of thyroid hormones?

A
  1. Regulates metabolic rate.
  2. Regulates growth and development by protein production.
  3. Regulates sensitivity of cells to other hormones.
19
Q

What cell type produces calcitonin?

A

Parafollicular (C) cells.

20
Q

Where do the parathyroid glands develop from?

A

Wall of pharynx.

21
Q

What hormone is produced from parathyroid glands?

A

PTH.

22
Q

What does the adrenal cortex develop from?

A

Mesoderm of posterior abdominal wall.

23
Q

What does the adrenal medulla develop from?

A

Neural crest cells in neuroectoderm.

24
Q

Name the three layers of epithelium that make up the adrenal cortex?

A
  1. Zona glomerulosa.
  2. Zona fasciculata.
  3. Zona reticularis.
25
Q

What is the general function of the adrenal cortex?

A

Produce steroid hormones.

26
Q

What does zona glomerulosa produce?

A

Mineralocorticoids e.g. aldosterone.

27
Q

What does zona fasciculata produce?

A

Glucocorticoids e.g. cortisol.

28
Q

What does zona reticularis produce?

A

Sex steroids e.g. androgens.

29
Q

What is the general function of adrenal medulla?

A

Contains chromatin cells to produce catecholamines.

30
Q

Name three catecholamines.

A
  1. Adrenaline.
  2. Noradrenaline.
  3. Dopamine.
31
Q

Cushing’s syndrome is associated with a prolonged exposure to what?

A

Cortisol.

32
Q

What are the signs and symptoms of Cushing’s syndrome?

A
  1. Hypertension.
  2. Abdominal obesity but with thin arms and legs.
  3. Round red face.
  4. Red stretch marks.
33
Q

What does the pineal gland secrete?

A
  1. Melatonin.

2. Serotonin.