What two things are indicative of liver damage?
- Alanine Transaminase (ALT)
2. Low level of alpha-1 antitrypsin
Inactive protein precursor that is converted to an enzyme when activated
What activates Zymogen from going inactive to active?
How is Thrombin generated?
From prothrombin by two proteolytic cleavages performed by prothrombin converting complex
What consists of prothrombin-converting complex?
Calcium, phospholipids and 2 blood coagulation proteins (factor V and factor X)
T/F: The two cleavages from prothrombin to thrombin leas to an irreversible activation of thrombin
Warfarin, a vitamin K analog, is used to treat what time of disorder?
Thrombosis (blood disorder): blood coagulates too readily
How do you inactivate thrombin?
High affinity binding of antithrombin
What is alpha1-antitrypsin?
Inhibitor of elastase hence protects tissues
What can change the charge of an amino acid?
Phosphorylation & Dephosphorylation
What do Competitive Inhibitors NOT alter?
Noncompetitive inhibitors reduce _______
Vmax/amount of enzyme present