ENZYME REGULATION L11 Flashcards Preview

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Flashcards in ENZYME REGULATION L11 Deck (12)
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1
Q

What two things are indicative of liver damage?

A
  1. Alanine Transaminase (ALT)

2. Low level of alpha-1 antitrypsin

2
Q

Define Zymogen

A

Inactive protein precursor that is converted to an enzyme when activated

3
Q

What activates Zymogen from going inactive to active?

A

Proteolytic cleavage

4
Q

How is Thrombin generated?

A

From prothrombin by two proteolytic cleavages performed by prothrombin converting complex

5
Q

What consists of prothrombin-converting complex?

A

Calcium, phospholipids and 2 blood coagulation proteins (factor V and factor X)

6
Q

T/F: The two cleavages from prothrombin to thrombin leas to an irreversible activation of thrombin

A

True

7
Q

Warfarin, a vitamin K analog, is used to treat what time of disorder?

A

Thrombosis (blood disorder): blood coagulates too readily

8
Q

How do you inactivate thrombin?

A

High affinity binding of antithrombin

9
Q

What is alpha1-antitrypsin?

A

Inhibitor of elastase hence protects tissues

10
Q

What can change the charge of an amino acid?

A

Phosphorylation & Dephosphorylation

11
Q

What do Competitive Inhibitors NOT alter?

A

Vmax

12
Q

Noncompetitive inhibitors reduce _______

A

Vmax/amount of enzyme present