Ephedrine Vs Phenylephrine

Question 1

Eph and Phen are both…

Answer 1

Synthetic non-catecholamines

Question 2

Receptors of Eph and Phen?

Answer 2

A1 and min B’s (Phen is def > A1 “all day long”)

Question 3

Duration and Onset of Eph and Phen:

Answer 3

Eph: Duration 15-20 mins
Onset 1-3 mins
Phen: Duration 10-20 mins
Onset 1-3 mins

Question 4

Is Phen as good as Eph in > uterine BF?

Answer 4

Yes. *in some study.

Question 5

Does Eph > myocardial contractility?

Answer 5

Yes

Question 6

What SE can occur with Eph?

Answer 6

Tachyphylaxis

Question 7

Is Phen OK to use in pregnant Pts?

Answer 7

Yes

Question 8

How is Eph like/different than Epi?

Answer 8

“Like epi but BP response is < and last longer”.

Question 9

How is Phen like/different than NE?

Answer 9

“Like NE but less potent and last longer”.

Question 10

What is a major SE of Phen?

Answer 10

Reflex Bradycardia

Question 11

What vasoconstrictor can cause psychosis?

Answer 11

Eph, > lipophilic can cross into CNS.

Question 12

How does Eph > CO?

Answer 12

By > Preload and Contractility (B1)

> Venoconstriction than arterial constricion

Question 13

How does Phen > CO?

Answer 13

By > Preload and > Afterload
(Does > PA resistance and pressure)
>SBP and > DBP

Question 14

Does Eph have the benzo…ring and is it a catecholamine?

Answer 14

Yes

Not a catecholamine (synthetic non-catecholamine)

Question 15

Are primary effects of Eph indirect or direct?

Answer 15

Indirect

Question 16

Are there multiple routes of Epiderine?

Answer 16

NO?

But Phen does have multiple routes of administration.

Question 17

Why is there reflex bradycardia with Phen?

Answer 17

“I don’t want to push up against this”

Question 18

What does Phen do with renal and splenic BF?

Answer 18

Decreases

Question 19

Can Phen cause dysrhythmias?

Answer 19

Not generally as a direst effect.

Question 20

Does Eph constrict of relax bronch muscles?

Answer 20

Relax

(Phen > PAP