MIDTERM

Question 1

EPINEPHRINE

Answer 1

Catecholamine
A1 (most potent), B1, B2
Low dose (1-2) B2, 10), A1 REFLEX BRADYCARDIA
No CNS effects, < RBF

Question 2

NOREPINEPHRINE (Levophed)

Answer 2

Catecholamine
A1 (min B1+B2)
REFRACTORY HYPOTENSION
>CO @ low dose, MAP

Question 3

RACEMIC EPINEPHRINE

Answer 3

Mixture of levo + dextrorotatory
Constricts edematous mucosa
Tx croup + Airway edema
Watch for 2 hours post admin for rebound

Question 4

EPHEDRINE

Answer 4

Synthetic Non-Catecholamine
A1 “hint of B”
> Uterine BF
> Myocardial contractility
TACHYPHYLAXIS
Lipophilic
Indirect effects

Question 5

PHENYLEPHRINE

Answer 5

Synthetic Non-Catecholamine
A1 “all day long”
REFLEX BRADYCARDIA
< RBF
Can use in pregnant Pts
“Might be as good as EPH of OB uterine BF”
> Pulm Art resistance and pressure

Question 6

DOPAMINE

Answer 6

Catecholamine

A+B

Question 7

VASOPRESSIN

Answer 7

Posterior Pituitary Hormone (ADH)
Does not lose effect in Acidic environment while EPI will.
V1: G-coupled Ca influx arterial constriction
V2: ADH renal collecting duct
No > in O2 consumption
Is as effective as EPI, no benefit giving together.

Question 8

Giapreza

Answer 8

Synthetic human angiotensin II
> BP in adults in septic shock (and other shocks)
Last line of defense
>risk for DVTs