EPI 1.0 Flashcards
(99 cards)
define an emerging infectious disease
One that has appeared in a population for the first time, or that may have existed previously but is rapidly increasing in incidence or geographical range
List the 5 main reasons diseases are emerging and spreading
1) Ecological changes or disruption (climate change)
2) Introduction of animals/people to new areas
3) Increasing global movement (people and animals)
4) Cultural changes and changes to agriculture practices
5) Enhanced diseases surveillance and detection
What about ecological changes or disruption leads to emergence of disease and what are the 3 important factors
Changes in precipatation, extreme weather events (droughts and floods) and seasonal shifts can directly impact disease agents, vectors and hosts and their interactions
1) Disease agents -> altered pathogen survival, replication or distribution
2) Vectors -> changes to habitat, vector distribution, altered contact with hosts
3) Hosts: stress, debilitation, malnutrition, or post-disaster injury as populations response to extreme weather events Disease agents with external (eg, nonhost) portions to their life cycles are more likely to be influenced by ecological change (i.e. parasites and food-, water-, and vector-borne diseases)
Give an example of how an emerging disease occurred due to ecological change or disruption
Emergence of bluetongue virus in Europe - Transmission of BTV is affected by temperature due to intermediate host (Culicoides)
1) Extrinsic incubation is faster
2) Vector number increase
3) Vector distribution expands
Introduction of animals/people to new areas what is it driven by and how does it lead to emerging diseases
- Driven by many factors
○ Climate change and environmental factors
○ Agriculture/urbanisatin on nautral ecosystems
○ Displacement of people due to political, social or economic - Bring domestic animals and people into contact with wildlife and their infectious agents
- Infections can then be transmitted from wildlife hosts to domestic animals -> spillover events
Give 2 examples of how introduction of animals/people to new areas lead to the emergence of diseas
1) Hendra virus: fruit bats -> horses -> humans (Australia)
2) Nipah virus: fruit bats -> (pigs) -> humans (Malaysia and Bangladesh)
What makes bats a good vector for disease transmission
1) Bats have some unique immunological features
- can have more persistent viral infections
- can be more susceptible to reinfection
2) Bats have behavior characteristics that favor virus transmission
- live in large populations
- migrate large distances
- live in close proximity to human populations
increasing global movement what are the 2 main ways it leads to emergence of diseases
1) Movement of people and animals is not new just the scale and speed of movement has increased dramatically in recent history
○ Sea and land travel
○ Air travel -> easier to control due to restriction on products that can take with you
2) The incubation period of many infectious diseases in now longer then the time it takes to circumnavigate the globe
○ Can no longer control More than 1 billion international travels per year
Give an example of a disease that emerged from increasing global movement
Emergence and spread of H1N1 in 2009 - H1N1 pandemic in 2009 - 2010
- Emerged in Veracruz , Mexico
- Rapid global spread, despite control efforts (closure of public facilities, travel restrictions, travel warnings)
- Very highly studies pandemic
- Mortalities estimate to be 300,000 to 500,000 (normal seasonal influenza)
Cultural changes and changes to agriculture practices how does this mainly lead to emergence of disease
A rapidly expanding global population, and increased demand for animal protein in developing countries with rising incomes, is driving increased production of meat and other animal food products
- Increase demand for animal protein contributes to
○ Intensification of animal production systems
§ Spread of infectious disease
§ Waste management problems
○ Use of in-feed problems
§ Emergence and spread of antibiotic resistance
□ Via the food chain
□ Via a contaminated environment
□ Resistance genes can spread to other bacteria
Enhanced disease surveillance and detection how does this result in emergence of new disease and the 2 ways these are identified
Enhanced surveillance systems and improved methods of detecting pathogens contribute to the identification of new disease agents
1) PCR requires some knowledge of the infectious agents
§ Some sequence information is required for primer design
2) Newer ‘high throughout’ DNA sequencing technologies can detect and identify infectious agents without targeted PCR amplification
§ Very well suited to the detection of novel pathogens
§ Can reveal whole genome sequence information
What are the 7 main roles of clinical veterinarians in emerging diseases
- Protect themselves - PPE, hygiene, infection control
- Protect their staff - supervise and advise on PPE, hygiene, infection control
- Protect clients - advise on PPE, hygiene, infection control
- Disease detection - recognise and report diseases
- Assist with disease surveillance in animals
- Assist in outbreak investigation and control
- Work with human health professional and other scientists in controlling any animal reservoirs of human infections
List 5 roles of government, university veterinarians
- Laboratory diagnosis and detection of disease agents
- Co-ordinate animal surveillance and idsease ocntrol measures
- Liaise with media, politicians, industry, other stakeholders
- Research (vaccine development, pathogenesis, epidemiology)
- Policy development
List some difference between the veterinary and medical professions
1) Herd animals are usually managed as a group with few rights for the individual animal; not the case in human medicine
2) For vets quality of life of their patient is more important than life itself; for doctors life is paramount
3) Economic issues are a very important factor in veterinary decisions (life and death at times); costs only modify management for doctors
4) Consent of owner not always critical for vets as consent can often be overruled by legislation; consent of patient or guardian is very important for doctors (very difficult to overrule)
5) Animals can be killed because they are ill, suspected of being ill, or close to another ill animal; not so for humans
6) Vets have more power to enforce their decisions; doctors have to convince patients and populations to do what is best
List 7 main impacts of emerging infectious disease and examples within
1 ) Animal health and welfare - Animal illness/deaths from disease - Culling
2) Human Health - Human illness/death from disease - Psychological distress
3) Economic impacts - Direct (loss of animals, loss of production) - Indirect (associated industries, tourism)
4) Social impacts - Loss of livelihoods, movement restrictions
5) Trade restriction - Animals and animal products
6) Environmental - Carcass disposal, use of chemicals, PPE (single use - more plastic, disinfecting with chemicals)
7) Political
What are the 2 main areas of economic impacts from FMD 2001 outbreak and how affected
AGRICULTURE & FOOD INDUSTRY
- Ban on British exports of livestock, meat and animal products
- Culling for disease control measures or welfare reasons
- Production losses, disease eradication costs, trade disruption
- Agricultural producers (animals), Agricultural producers (feed), Food industry (auction markets, abattoirs, processors, transporters)
TOURISM - Tourists changed their plans, delayed trips, cancelled trips, switched destinations within UK
- Accommodation, catering, attraction and transport TOTAL - 8.6 billion pound
2001 FMD outbreak what was the main environmental and human health impacts
Environmental -> disposal of dead carcasses
Human health ->
- Not a zoonotic disease
- Significant psychosocial effects
○ Vets getting death threats ○ seeing the animals burning on pyres -
Not just farming communities
○ Distress
○ Feeling of bereavement ○ Fear of new disaster
○ Loss of trust in authority and systems of control
What are the main animal health and welfare impacts for FMD outbreak in 2001
1) Animal welfare impacts related primarily to control measures
- Mass culling of healthy/uninfected animals for disease control
- Mass culling of healthy/uninfected animals due to welfare concerns arising from movement restrictions
2) Animals couldn’t be transported to abattoirs, mass culling in the field
- Reduced options for killing methods
- Lack of suitable equipment
- Lack of suitably trained people
- Lack of suitable facilities (including restraint)
- Fatigue (staff and equipment)
What are the political impacts of the FMD 2001 oubreak
Loss of public confidence in government Conduct and policies of MAFF heavily criticized
- Underprepared - Unwillingness to use vaccination
- Poor coordination and mismanagement (early days of outbreak)
- Use of the army - Confrontation attitude towards farmers and farming communities
- Failure to recognize the impact of movement restrictions
- Failure to pay adequate and timely compensation
- No public inquiry (3 policy inquiries) ○ Vaccination to be considered in any future outbreaks
what are the main differences with animals used as food in hunter/gather societies to agriculture societies
Hunter/gather ○ Different hunting/endurance hunting - cruel way § Persistence/endurance hunting § Spears § Bow and arrows § Throwing sticks, boomerang Agriculture societies ○ Domesticated animals ○ Slaughter +/- stunning ○ Consideration for animal welfare ○ Modern abattoirs
what are the main features of a modern abattoir
- Stunning prior to slaughter
- Abattoir design to minimise animals stress, maximise animal welfare
- Protocols/procedures in place to maximise animal welfare at all stages
○ Transport
○ Lairage - holding yards before go into the abattoir
○ Stunning
○ Slaughter - Design and protocols/procedures to maintain food safety/worker safety
What are the 2 steps involved in the humane slaughter of livestock in an abattoir and what is involved with each
1) Stunning - is performed to render the animal unconscious and insensible to pain priot to slaughter
- Slaughter can then be carries out painlessly (and safety for abattoir workers) - MUST BE DONE IN AUSTRALIA prior to slaughter
2) Slaughter occurs after stunning
- Blood vessels carrying oxygenated blood to the brain are severed (“sticking”)
- The result is death from lack of oxygen to the brain (cerebral anoxia)
What are the 2 different stunning methods, define them, what is important and which is mainly used in AUS
1) Reversible stunning methods - animals is able to recover sensibility
- The brain function of the animal must be stopped by another means (by severing blood vessels carrying blood to the brain
- The period of insensibility needs to continue until death supervenes
- Halal requires reversible stunning - MAIN USED IN AUSTRALIA DUE TO EXPORT
2) Irreversible stunning methods -
animal will die if not slaughtered ‘sticking’ is still performed so that the animals ‘bled out’ before further processing and to guard against any unexpected return to sensibility following stunning
What are the 3 reversible stunning methods and the 2 irreversible stunning methods
Reversible 1) head only electrical stunning 2) non penetrative captive bolt 3) CO2 stunning Irreversible 1) head to back electrical stunning 2) penetrative captive bolt stunning