Epstein Barr Virus (EBV) C2

Question 1

Burkitt

Answer 1

Unusual lymphoma

Question 2

Ebv affect which lymphocyte?

Answer 2

B lymphocyte

Question 3

Ebv infection leads to?

Answer 3

Latency
Periodic reactivation
Life long persistence

Question 4

Source of Ebv infection?

Answer 4

Saliva

Question 5

EBV

Answer 5

Occur in children and infants
Humans are the only natural host

Oropharyngeal secretion
Primary inf
Intermittent

It is not highly contagious

Question 6

Mode of transmission ?

Answer 6

Intimate oral contact (kissing)

Question 7

Another name for EBV

Answer 7

Kissing disease

Question 8

Ebv replication takes place where

Answer 8

In epithelial cells and encodes many proteins

Question 9

EBV Glycoproteins ?

Answer 9

Gp350/220 - attachment to CD21

and Gp85-membrane fusion

Question 10

Cells that expresses CD21

Answer 10

Mature B cell
Stratified squamous epithelium e.g salivary gland
Oropharynx
Ectocervix

Question 11

Pathogenesia of EBV?

Answer 11

Ebv enters- the pharyngeal epithelial cells- multiplies locally-bloodstream-infect b lymphocyte

Question 12

Two types of changes in B cells?

Answer 12

One type- virus become latent inside B cells

Indifinite growth of B cell
Becomes immortalised/transformed
Produces igm, G, A
Igm contains heterophile antibodies 
Virus antigen express on the surface 
B cell proliferation 
Intermittent reactivation of latent EBV leads to proliferation of infected B cell

Second type- virus lyses the B cell and cause cell death& release of nature progeny virions

Atypical lymphocyte sewn in blood smear
Most immunodeficiency patients have lymphoma containing EBV
X-linked lymphoproliferative syndrome or Duncan is associated with susceptibility to EBV

Question 13

Clinical features of EBV?

Answer 13

Infectious mononucleosis / glandular fever
Primary inf seen in 15-25 years age group

Incubation period 30-50 days
Onset with- sore throat
Cervical lymphadenopathy 
Fevered
Pharyngitis with greyish 
 membrane
Intermittent fever $ sweating- over 2weeks

Transient morbiliform rash
Hepatitis - subclinical level
Maculopapular rash - may follow ampicillin administration

Airway obstruction due to lymphoid enlargement and edema

Neurological- meningitis

Encpahalitis
Gillian barre syndrome

2. EBV & malignancies
   A. Burkitt lymphoma
   B. EBV -associated nasopharyngeal
   carcinoma
3. EBV in HIV and immunocompromised- hairy leukoplakia (white grey lesion on tongue)

Question 14

Lab diagnosis of EBV?

Answer 14

Leukopenia
Leukocytosis
Abnormal mononuclear cells(basophillic& kidney shaped nuclei)

Paul bunn test - standard diagnosis

Heterophile ab- agglutinates sheep red cells

Question 15

Treatment of EBV

Answer 15

Acyclovir