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Microbiology (viruses) > Herpes Virus > Flashcards

Herpes Virus Flashcards

1
Q

Where is viral envelop derived from?

A

Host cell nuclear membrane

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2
Q

Which is tegument?

A

A structural protein btw envelop and capsid

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3
Q

Types of herpes virus?

A 
HSV 1$2
Varicella zoster virus
Epstein Barr virus
Cytomegalovirus 
Human herpes virus 678
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4
Q

Class of herpes virus?

A

Alpha (HSV $ VZV)- sensory ganglia inf
Beta (CMV)- salivary gland $ organ inf
Gamma ( EBV)- B $ T cell inf

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5
Q

Types of Herpes simplex virus

A

Type 1$2

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6
Q

HSV 1?

A 
Mouth inf
Spread by direct contact 
Infection above waist
Virus remains latent in ganglia 
Trigeminal nerve- nerve of the face
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7
Q

HSV 2?

A

Genitalia inf
Spread by venereal- sex
Inf below waist
Sacral nerves

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8
Q

Envelop of HSV contains?

A

Glycoproteins B D H

B$D- absorption and penetration into host cell

H- release of the virus

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9
Q

Pathogenesis of HSV?

A 
Virus enter through defects skin/ mucous
Multiply locally
Enters the cutenous nerve fibers
Replication in ganglia
Migration to skin/ mucosa.

Causes cutenous and mucosa lesion.

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10
Q

Clinical manifestation of HSV?

A

Depends on site of inf, age, immune status of host, antigenic type of virus

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11
Q

Lesion on buttocks of infant?

A

( napkin rash)

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12
Q

Cutenous inf of HSV looks like?

A

Thin walled vesicle
A ballooning
Degeneration of intra epithelial cells

The underlying basal layer is usually intact with the vesicle

The base of vesicle contains multi nuclear cells (Tzanck cells) with eosinophillic inclusion bodies

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13
Q

The base of the vesicle in HSV contains?

A

Tzanck cells with eosinophilic inclusion bodies

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14
Q

What happens when the vesicle of HSV cutenous lesion breaks down?

A

Ulcer forms in the mucous $ non-keratinizing epithelia

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15
Q

The lesion in fever blister/ herpes fibrils is caused by?

A

Virus deactivation in febrile ( showing sign of fever) patient

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16
Q

Occupational cutenous herpes?

A

Hermetic whitlow seen in doctors, dentist and nurses

17
Q

Eczema herpeticum (kaposi varicelliform) of cutenous inf of HSV?

A

Eruption caused by herpes inf in children with eczema

Arises from pre-existing skin disease usually atopic dermatitis

18
Q

Mucosal inf of cutenous inf in HSV?

A

Buccal mucosa is the most common site
Gangivostomatittis
Pharyngitis - most frequent in primary $ recurrent inf

19
Q

Opthalamic inf of cutenous inf in HSV?

A

Acute keratoconjuctivitis ( itself or by extension from facial herpes)

Most common cause of corneal blindness

20
Q

Follicular conjunctivitis in Cutenous inf of HSV

A

Vesicle on eyelids

Cornea may be involved with typical branching dendritic ulcers

21
Q

Nervous system inf of HSV?

A

HSV encephalitis- acute onset with fever
Focal neurological symptoms

HSV meningitis- self limiting disease usually leave in a week

Rarely transverse myelitis or Gillian barre syndrome

22
Q

What causes sacral autonomic dysfunction

A

Nervous system inf of HSV

23
Q

What can cause bell’s palsy

A

HSV ( nervous inf)

24
Q

Visceral inf ofHSV?

A

HSV esophagitis causes dysphagia, substernal pain, weight loss

Respiratory tract inf causing tracheobronchitis, pneumonitis

Erythema multiforme

25
Q

Genitalia inf of HSV?

A

Lesion on penis, urethra, cervix, vulva, perineum

Primary inf is usually more serious
Fever and malaise

Vesicular-ulcerated lesion may be painful

26
Q

Congenital inf of HSV

A

Transplacental inf - congenital malformation

If mother has HSV1- fetus multi organ involvement with or without encephalitis

Mortality rate is high

If mother has HSV 2- post neonatal inf common in eye , mouth and skin
Caserian section may prevent inf to the neonate

27
Q

Diagnosis of HSV?

A

Tzanck cell smear with Toluidine blue o or giemsa stain
FAT
PCR
Isolation from amnion cell, embryonic kidney cell, chick embryo
ELISA
NEUTRALIZATION TEST
COMPLEMENT FIXATION TEST
CHEMOTHERAPHY - idoxyuridine ( topical use for skin and eye inf)

Acyclovir$ vidarabine- management of deep and systemic inf
Acyclovir - to avoid encephalitis

Valaciclovir $ famiciclovir are more effective as oral agents

Microbiology (viruses) (12 decks)

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