RSV...Measles

Question 1

introduction

Answer 1

in 3rd world - 900,000 death per year

causes fever, respiratory symptoms & macullopapularl rash (FRM)

Question 2

pathogenesis and pathology

Answer 2

human are the only natural host

• the virus enter the body trudgen’s respiratory tract where they multiply locally
• the inf spreads to the regional lymphoid tissues (further multiplication)
• primary viremia -spread the virus to reticuloendothelial system
• secondary viremia- shows in the epithelial surface of the body e.g skin, respiratory tract, conjunctiva (focal replication)

Question 3

measles can replicate in certain lymphocytes, yes or no

Answer 3

yes

Question 4

what is seen in lymphoid tissue throughout the body?

Answer 4

multinucleate gains cells with intranuclear inclusions

Question 5

What occurs during the incubation period (8-12days)

Answer 5

PRODORMAL PHASE (2-4days)
virus is present in tears, nasal/troat secretion,urine, blood

ERUPTIVE PHASE- abt 14 (5-8days)days the maculopapular rash will appear and circulating ab becomes detectable

Question 6

when viremia disappears what happens

Answer 6

fever falls

Question 7

rash develops as a result of

Answer 7

interaction btw immune t cell and virus in the small blood vessel

Question 8

rash last for how long

Answer 8

1 week

Question 9

is CNS involvement common or not

Answer 9

yes it is

Question 10

cns involvement

Answer 10

symptomatic encephalitis- 1:1000 cases

rarely recovers from the brain

Question 11

progressive measles inclusion body encephalitis occurs when?

Answer 11

patients is cell mediated immunity defective

Question 12

clinical findings

Answer 12

PRODORMAL PHASE
fever, sneezing,coughing,redness of the eye, running nose, lymphopenia, koplik spots

cough&coryza- intense inflammatory reaction in the mucosa of respiratory tract

conjunctivitis is associated with photophobia

kopek spot- small bluish-white ulceration on the buccal mucosa opposite the lower molar
-rash begins on the head-chest-trunk-limbs
otits media
pneumonia
pulmonary complications
giant cell pneumonia in defective immune cells
cns involvement is serious

subacute sclerosing pan encephalitis- rare complication ; it begins 5-15 years after measles inf and causes progressive mental deorientation
involuntary movements
muscular rigidity
coma
it is usually fatal within 1-3 years after onset

Question 13

koplik spot contains

Answer 13

giant cells and viral antigen

Question 14

light pink discreet maculopapules coalesce to form?

Answer 14

blotches becoming brownish in 5-10days

Question 15

in partially immune person, modified measles occurs as?

Answer 15

prodromal illnesss without koplik spot

Question 16

most common complication of measles

Answer 16

otitis media

Question 17

most common life threatening complication of measles

Answer 17

pneumonia- secondary bacteria inf

Question 18

90% of measles death is due to?

Answer 18

pulmonary complications

Question 19

giant cell pneumonia occurs in?

Answer 19

children and adult with defective immune cells

Question 20

the most serious complication of measles

Answer 20

CNS involvement

Question 21

late complication of measles inf

Answer 21

subacute sclerosis panencephalitis

Question 22

immunity

Answer 22

only one antigenic type of measles occurs and it gives life long immunity

local inflammation causes prodromal illness
specific cell mediated immunity develops the rashes