Equations

Question 1

Volume of distribution (Vd)

Answer 1

Vd = (dose x f)/Cp

f = bioavailability

Cp = concentration of plasma

Question 2

Clearance (CL)

Answer 2

CL = dose rate/ Cp_ss

Cp_ss = Contration of plasma at steady state

Question 3

Half life (t_1/2)

Answer 3

t_1/2 = (ln[2] x Vd)/ CL

Vd = volume of distribution

CL = clearance

Question 4

maintenance dose (MD)

Answer 4

MD =