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HEMA1 > Erythrocyte Disorders > Flashcards

Erythrocyte Disorders Flashcards

1
Q

Process of blood production

A

Hematopoiesis

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2
Q

Intrauterine hematopoiesis

A

Mesoblastic phase
Hepatic phase
Myeloid/medullary phase

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3
Q

Begins at 19th day of gestation

A

Mesoblastic phase

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4
Q

Mesoblastic phase hemoglobin

A

Gower 1
Gower 2
Portland

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5
Q

Primitive nucleated erythroblast (first cell)

A

Mesoblastic phase

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6
Q

Begins at 6 weeks of gestation

A

Hepatic phase

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7
Q

Produce during hepatic phase

A

RBC, granulocytes, monocytes, and megakaryocytes
Alpha and gamma globin (HbF)

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8
Q

Begins at 5th month of gestation

A

Medullary phase

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9
Q

Myeloid - erythroid ratio

A

3:1 (4:1)

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10
Q

Bone marrow producing mainly granulocytes

A

Medullary/myeloid phase

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11
Q

At when gamma-beta globin switch

A

6th month

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12
Q

Percentage of newborn active bone marrow

A

80-90%

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13
Q

60% of BM are active

A

Young adult (age 20)

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14
Q

Proximal ends of large flat bones, pelvis and sternum

A

Young age (20)

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15
Q

40% of BM are active and 60% is fat

A

Older adult (55)

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16
Q

Ratio of marrow cells to fat (red/yellow BM)

A

Cellularity

17
Q

Normocellular

A

30-70% hematopoietic cells

18
Q

Hypercellular/hyperplastic

A

> 70% hematopoietic cells

19
Q

Hypocellular/hypoplastic

A

<30% hematopoietic cells

20
Q

Marrow had few or no hematopoietic cells

A

Aplastic

21
Q

Ratio of granulocytes to nucleated erythroid precursor

A

M:E ratio

22
Q

Excluded from M:E ratio

A

Lymphocyte
Monocyte

23
Q

Pluripotential stem cell

A

Hematopoiesis

24
Q

Committed progenitor cells
(Lymphoid or myeloid)

A

Hematopoiesis

25
Q

What are the committed progenitor cells

A

CGU-MEG
CFU-GM (CFU-M)
CFU- GM (CFU-G)
BFU-E (CFU-E)
CFU-Eo
CFU-Bs

26
Q

Mature cell under thrombopoietin, GM -CSF

A

Thrombocyte

27
Q

Mature cell under CFU-M

A

Monocyte

28
Q

CFU-G mature cell

A

Neutrophil

29
Q

BFU-E mature cells

A

Erythrocyte

30
Q

IL-3, IL-4 mature cell

A

Basophil

31
Q

Growth factors of monocyte

A

GM-CSF, M-CSF, IL-3

32
Q

GM-CSF, G-CSF, IL-3

A

Neutrophil

33
Q

Erythrocyte growth factor

A

Erythropoietin, GM-CSF, IL-3

34
Q

Eosinophil interleukins

A

GM-CSF, IL-3, IL-5

35
Q

IL-3, IL-4

A

Basophil

HEMA1 (8 decks)

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