Erythrocyte Disorders

Question 1

Process of blood production

Answer 1

Hematopoiesis

Question 2

Intrauterine hematopoiesis

Answer 2

Mesoblastic phase
Hepatic phase
Myeloid/medullary phase

Question 3

Begins at 19th day of gestation

Answer 3

Mesoblastic phase

Question 4

Mesoblastic phase hemoglobin

Answer 4

Gower 1
Gower 2
Portland

Question 5

Primitive nucleated erythroblast (first cell)

Answer 5

Mesoblastic phase

Question 6

Begins at 6 weeks of gestation

Answer 6

Hepatic phase

Question 7

Produce during hepatic phase

Answer 7

RBC, granulocytes, monocytes, and megakaryocytes
Alpha and gamma globin (HbF)

Question 8

Begins at 5th month of gestation

Answer 8

Medullary phase

Question 9

Myeloid - erythroid ratio

Answer 9

3:1 (4:1)

Question 10

Bone marrow producing mainly granulocytes

Answer 10

Medullary/myeloid phase

Question 11

At when gamma-beta globin switch

Answer 11

6th month

Question 12

Percentage of newborn active bone marrow

Answer 12

80-90%

Question 13

60% of BM are active

Answer 13

Young adult (age 20)

Question 14

Proximal ends of large flat bones, pelvis and sternum

Answer 14

Young age (20)

Question 15

40% of BM are active and 60% is fat

Answer 15

Older adult (55)

Question 16

Ratio of marrow cells to fat (red/yellow BM)

Answer 16

Cellularity

Question 17

Normocellular

Answer 17

30-70% hematopoietic cells

Question 18

Hypercellular/hyperplastic

Answer 18

> 70% hematopoietic cells

Question 19

Hypocellular/hypoplastic

Answer 19

<30% hematopoietic cells

Question 20

Marrow had few or no hematopoietic cells

Answer 20

Aplastic

Question 21

Ratio of granulocytes to nucleated erythroid precursor

Answer 21

M:E ratio

Question 22

Excluded from M:E ratio

Answer 22

Lymphocyte
Monocyte

Question 23

Pluripotential stem cell

Answer 23

Hematopoiesis

Question 24

Committed progenitor cells
(Lymphoid or myeloid)

Answer 24

Hematopoiesis

Question 25

What are the committed progenitor cells

Answer 25

CGU-MEG CFU-GM (CFU-M) CFU- GM (CFU-G) BFU-E (CFU-E) CFU-Eo CFU-Bs

Question 26

Mature cell under thrombopoietin, GM -CSF

Answer 26

Thrombocyte

Question 27

Mature cell under CFU-M

Answer 27

Monocyte

Question 28

CFU-G mature cell

Answer 28

Neutrophil

Question 29

BFU-E mature cells

Answer 29

Erythrocyte

Question 30

IL-3, IL-4 mature cell

Answer 30

Basophil

Question 31

Growth factors of monocyte

Answer 31

GM-CSF, M-CSF, IL-3

Question 32

GM-CSF, G-CSF, IL-3

Answer 32

Neutrophil

Question 33

Erythrocyte growth factor

Answer 33

Erythropoietin, GM-CSF, IL-3

Question 34

Eosinophil interleukins

Answer 34

GM-CSF, IL-3, IL-5

Question 35

IL-3, IL-4

Answer 35

Basophil