Hemolytic Anemia Due To Metabolic Disorder Flashcards
Hemolytic due to metabolic disorder
- G6PD Deficiency
- Pyruvate Kinase deficiency
- Pyrimidine-5-Nucleotidase
- Glucose phosphate isomerase deficiency
- Triosephosphate isomerase, hexokinase and diphospholgycerate mutase deficiencies
- Glutathione synthetase, glutathione peroxidase and glutathione reductase deficiencies
Sex linked; complex heterogenous disorder which is ubiquitous
G6PD Deficiency
Enzyme deficit hemolytic anemia
G6PD Deficiency
Type A, type B , Favism
G6PD Deficiency
Most common red cell enzyme deficiency
PK Deficiency
PK Deficiency involved _________
Embden-Meyerhof glycolytic pathway
PK converted to _______________
Phosphophenolpyruvate
Abnormality in nucleotide metabolism
PN deficiency
PN acquired occurs in
Lead poisoning (basophilic stippling)
Abnormalities in anaerobic glycolysis
Glucose phosphate isomerase deficiency
Red cell shows anisocytosis and poikilocytosis
Glucose phosphate isomerase deficiency
Other enzyme deficiencies that involve anaerobic glycolysis
Triosephosphate isomerase, hexokinase and diphospholgycerate mutase deficiencies
Show hemolytic anemia; required in the HMP like G6PD
Glutathione synthetase, glutathione peroxidase and glutathione reductase deficiencies
Hemolysis increase due to _________ exposure or infection
Oxidant drug
Extrinsic hemolytic anemia
Vegetables and animal poison
Infectious agent
Physical agent
Autoantibodies, isoantibodies or drug related antibody
Chemical agent
VIPAC
