erythrocyte disorders Flashcards
(26 cards)
impaired DNA metabolism is characteristic of
Megaloblastic anemia
which of the following is associated with glucose-6-phosphate dehydrogenase (G6PD) deficiency?
a. G6PD gene is located on the x chromosome
b. ongoing intravascular hemolysis occurs
c. all circulating red cells, including reticulocytes, lack enzyme activity
d. splenectomy can relieve the rate of the red cell destruction
a. G6PD gene is located on the x chromosome
in regard to variant hemoglobin E, alpha2 Beta2 26 Glu - Lys, which of the following statements is false?
a. there are two normal alpha chains
b. glutamic acid replaces lysine on position 26 of the beta chains
c. hemoglobin E is the second most common hemoglobin variant known
d. glutamic acid is normally found at position 26 of the beta chain
b. glutamic acid replaces lysine on position 26 of the beta chains
a 9-month-old male was seen in the emergency dept. with a femur fracture that had occurred from a fall down the stairs. upon physical examination, the physician noted hepatosplenomegaly, extreme pallor, and a slight arrythmia. a complete blood count revealed the following:
wbc: 12.2 x10^9/L
rbc:3.05x10^12/L
Hgb: 61 g/L
Hct: 0.20 L/L
MCV: 65.5 fL
MCH: 20pg
MCHC: 305 g/L
RDW: 25%
Hemoglobin electrophoresis:
Hgb A 0%
Hgb A2 3%
Hgb F 97%
which condition is most likely causing the hematologic abnormalities?
Cooley beta-thalassemia major
Pica is mostly associated with what condition?
iron deficiency
of the following, the leading cause of folate deficiency is?
a. increased requirements
b. dietary deficiency
c. drug inhibition
d. malabsorotion
b. dietary deficiency
which of the following statements about sickle cell syndromes is false?
a. asplenism may result from repeated sickling crises in the homozygous state
b. heterozygous persons may be partly protected from infection by falciparum malaria.
c. hemoglobin S is more soluble in dithionite than is in normal hemoglobin.
d. the conditions are generally asymptomatic with no sickle cell formation
c. hemoglobin S is more soluble in dithionite than is in normal hemoglobin.
which of the following blood findings does not correlate with the findings of a ringed sideroblast in the bone marrow?
a. pappenheimer bodies
b. basophilic stippling
c. increased TIBC
d. increased percent transferrin saturation
c. increased TIBC
which of the following conditions is not usually associated with marked reticulocytosis?
a. four days after a major hemmorrhage
b. drug-induced autoimmune hemolytic anemia
c. sickle cell anemia
d. pernicious anemia
d. pernicious anemia
hereditary stomacytosis is manifested physiologically by changes in
membrane cation permeability
which of the following is not charactetistic of aplastic anemia?
a. extramedullary hematopoiesis
b. bone marrow hypoplasia
c. absolute reticulocytopenia
d. blood findings of pancytopenia
a. extramedullary hematopoiesis
what values would you expect to obtain on hemoglobin and hematocrit determinations done immediately after a major hemorrhage, if hemoglobin and hematocrit values were normal prior to the hemorrhage?
a. both normal
b. both decreased
c. hemoglobin decreased, hematocrit normal
d. hemoglobin normal, hematocrit decreased
a. both normal
results from a 1-day-old infant include a hemoglobin 201 g/L, hematocrit of 0.60 L/L. MCV of 110.2 fL, and 4 nucleated red cells/100 WBCs.
How should these results be interpreted?
no further testing is indicated
a patient with normocytic, normochromic anemia secondary to small cell carcinoma may be exhibiting an anemia designated as
follows exposure to ionizing radiation
which of the following is a true red blood cell aplasia?
a. marrow replacement anemia
b. fanconi anemia
c. diamond-blackfan anemia
d. donath-landsteiner anemia
c. diamond-blackfan anemia
which of the following is not a cause of absolute secondary erythrocytosis?
a. defective cardiac pulmonary function
b. high-altitude adjustment
c. dehydration secondary to diuretic use
d. hemoglobins with increased oxygen affinity
b. high-altitude adjustment
a cellulose acetate hemoglobin electrophoresis (alkaline ph), performed on the blood of a stillborn infant, revealed a single band that migrated farther toward the anode than did the Hb A control. what is the most likely composition of the stillborn infant’s hemoglobin?
two alpha and two beta chains
a cellulose acetate hemoglobin electrophoresis (alkaline ph), performed on the blood of a stillborn infant, revealed a single band that migrated farther toward the anode than did the Hb A control. what is the most likely composition of the stillborn infant’s hemoglobin?
the most likely cause of the stillborn infant’s condition is
hydrops fetalis
which of the following conditions show similar cbc and blood smear findings?
folic acid and vitamin B12-deficiencies
which of the following conditions is not associated with the presence of schistocytes and spherocytes?
aplastic anemia
a 30-year old woman who has been vomiting for 3 days has a hemoglobin value of 180 g/L and a hematocrit value of 0.54 L/L her results suggests the presence of
relative polycythemia
an excessive accumulation of iron in the body tissues is called
hemochromatosis
abetalipoproteinemia is characterized by mild anemia and numerous _____ on the peripheral blood smear
acanthocytes
what is the most common cause of iron deficiency?
bleeding
