erythrocytes Flashcards
(38 cards)
the average lifespan of normal red blood cell
120 days
the Sodium-Potassium cation pump is an important mechanism in keeping the RBC intact. its function if to maintain a high level of
intracellular potassium
which of the following depicts the structure of the hemoglobin molecule?
four heme groups, four globin chains
describe the process known as CULLING
removal of abnormal red cell in the spleen
hemoglobin forms that are incapable of oxygen transport are
carboxyhemoglobin and methemoglobin
the majority of the iron found in an adult is a constituent of
hemoglobin
the senescent red blood cell is one that has
lived its lifespan/already old
what red cell morphologic abnormality is described by the term poikilocytosis?
deviations from normal shape
Howell-jolly bodies are composed of
DNA
When spherocytes are reported, what is observed on the peripheral blood smear?
red cells without central pallor
the red cells found in lead poisoning characteristically exhibit coarse granules composed of _____ that are reported as_____
aggregate ribosomes; basophilic stippling
Rouleaux of red blood cells when seen in the monolayer of a blood smear is characteristic of
multiple myeloma
which of the following statements about iron is true?
a. absorption occurs in the ileum
b. the mucosal cell always absorbs the correct amount of iron to meet needs.
c. absorption increases when erythropoietic activity increases
d. alkaline pH favors absorption
c. absorption increases when erythropoietic activity increases
what term describes a mature red blood cell that contains iron granules or deposits?
siderocyte
which of the following is associated with a “shift to the left” in the oxygen dissociation curve of hemoglobin?
a. decreased pH and elevated temperature
b. decreased oxygen affinity
c. decreased oxygen release
d. presence of 2,3-biphosphoglycerate (2,3-DPG)
c. decreased oxygen release
Which of the following statements does not characterize EPO (erythropoietin)?
a. transforms CFU-E into the earliest recognizable RBC precursor
b. increase the rate of red blood cell production by the bone marrow
c. shortens the maturation time of the developing eryhtroid precursors
d. decrease stimulation of erythropoiesis when cellular hypoxia increases
d. decrease stimulation of erythropoiesis when cellular hypoxia increases
which of the following result in the immediate increase in oxygen delivery to the tissues?
a. increase pH
b. high altitude
c. increase hemoglobin binding of 2,3-BPG
d. increased renal release of erythropoietin
c. increase hemoglobin binding of 2,3-BPG
periods of intense erythropoietin activity cause premature release of marrow reticulocytes into the blood. which of the following is not true of these early reticulocytes?
a. loss of residual RNA occurs immediately upon marrow release
b. circulate longer than usual before reaching maturity
c. may be termed shift or stress reticulocytes
d. show diffuse basophilia with Wright’s stain
a. loss of residual RNA occurs immediately upon marrow release
- it will take another day in the blood to release the RNA
the inclusion only visible with the Supravital staining
Heinz bodies
-basophilic stippling, cabot rings and pappenheimer are visible on wright and supravital stains
the presence of schistocytes on the peripheral blood smear is commonly associated with
increased red cell destruction
which of the following may be a sign of accelerated bone marrow eryhtropoiesis?
a. hypercellular marrow with a decreased number of RBC precursors
b. bone marrow M:E ratio of 6:1
c. nucleated cell in the peripheral circulation
d. low erythrocyte, hemoglobin and hematocrit levels
c. nucleated cell in the peripheral circulation
microcytic, hypochromic red cells are most often associated with impaired
hemoglobin synthesis
when acanthocytes are found on a blood smear, it is usually a result of
altered membrane lipids
which erythrocyte metabolic pathway generates adenosine triphosphate (ATP)?
Embden-Meyerhof
