hematopoiesis Flashcards
(20 cards)
the first type of cell produced by the developing embryo
erythrocytes
Percentage of fat tissue located in the bone marrow cavities of adults
50%
Characteristics of pluripotent hematopoietic stem cells
- possess self-renewal activity
- morphologically unrecognizable
- produce progenitor cells committed to a single cell lineage
in an adult, the two best areas of obtaining active bone marrow by aspiration
posterior iliac crest, and sternum
normal ratio of myeloid to erythroid precursors in bone marrow (M:E Ratio)
4:1
how would you accurately describe hematopoietic growth factor
- bind to target cell receptor to express activity
- can stimulate or inhibit cell proliferation
- may promote or suppress cell death
primary site of hematopoiesis in the 3rd month of gestation
liver
the mechanism that relays information about tissue oxygen levels to erythropoietin-producing sites is located in the
kidney
antigen-independent lymphopoiesis occurs in primary lymphoid tissue located in the
thymus and bone marrow
programmed cell death is called
apoptosis
in what area of the bone marrow does hematopoiesis take place
cords
bone marrow cellularity refers to the ratio of
hematopoietic tissue to adipose tissue
interleukins and colony stimulating factors are produced by
monocytes and T lymphocytes
what is the approximate total blood volume in an adult?
6 liters of 6,000 milliliters
the myeloid progenitor cell can produce cells committed to
Granulocytic, Eryhtrocytic, Monocytic, or megakaryocytic lineages
the largest hematopoietic cells in normal bone marrow are
megakaryocytes
when evaluating bone marrow aspirate smear, which finding is considered abnormal?
a. a predominance of granulocytes precursors as compared to nucleated red cells
b. detection and stainable iron in macrophages and erythroid precursors with prussian blue
c. an average of three megakaryocytes seen per low power (10x) field
d. the presence of 10% myeloblasts on the cell differential count
d. the presence of 10% myeloblasts on the cell differential count
as most blood cell lines mature, which of the following is characteristic?
a. cell diameter increases
b. N:C ratio increases
c. nuclear chromatin becomes less condensed
d. basophilia of the cytoplasm increases
b. N:C ratio increases
how would you describe a Thrombopoietin (TPO)?
Hormone produced by the liver that stimulates megakaryopoiesis
when the hepatic phase of the fetal life is reactivated in an adult, hematopoiesis can be termed
myeloid metaplasia or extramedullary
