Erythropoeisis Flashcards
(33 cards)
Erythropoeisis is a subclass of Hemapoeisis involving the production and development of —
Red blood cells (Erythrocytes)
In the HIM space, Erythropoeisis occurs in conjoined pockets of cells that equally perform Thrombocytopoeisis.
False. Erythropoeisis occurs in islands of cells close to the abluminal surface.
The myeloid committed stem cells, the initial progenitor cells for the Erythrocytes, are the first derivatives of the Pluripotential Stem Cells.
False. The myeloid stem cells are not the initial progenitors for the Erythrocytes.
The pluripotential stem cells are the most primitive cells in the bone marrow. They are called ‘stem cells’ because:
(i) They have the ability to undergo cell division leading to self-renewal.
(ii) They can mitotically divide and then be differentiated.
The two progenitor cells for Erythropoeisis are:
(i) The Burst-forming Unit, Erythroid (BFU-E).
(ii) The Colony-forming Unit, Erythroid (CFU-E).
The earliest cell in the Erythroid lineage that can be biochemically and morphologically identified is the —.
Proerythroblast. It is the earliest precursor cell for the Erythrocytes.
The presence of — and — on the membranes of the Erythroid progenitors are biochemical identifiers for them.
ABO Blood Group antigens, erythropoietin receptors.
On characteristics of the Proerythroblast:
Its coin circular nuclei is its most prominent feature.
True.
On characteristics of the Proerythroblast:
It has a thin nucleus and a thin rim of cytoplasm.
False. It has a large nucleus.
On characteristics of the Proerythroblast:
Its lack of hemoglobin makes its cytoplasm appear deep-bluish.
True.
Proerythroblasts are described as being non-hemoglobinized. However, trace amounts of Hb can still be discovered in its cytoplasm via the — reaction.
Feulgen
The average lifespan of a mature erythrocyte is about —
100-120 days.
Erythrocytes are brought to maturation in the —, — hours after their departure from the bone marrow.
Spleen, 48
In all, it takes roughly a total of — days to complete the production of the erythrocyte from Proerythroblast to mature stage.
7
About — of the 7 days necessary for production of a fully mature erythrocyte cell is dedicated to the move from proerythroblast to orthochromatic erythroblast stage.
5
The main function of the Erythrocyte is:
Reversible Oxygen Transport.
One of the following is not a function of the RBC:
(i) Production of energy to be utilized by its daughter cells.
(ii) Complexing with toxins such as carbon monoxide to prevent their buildup.
(iii) Blood buffering via the histidine components of hemoglobin.
(i) is False. RBCs lack mitochondria, so they don’t produce energy.
What makes erythrocytes perfect transporters of body oxygen?
Their lack of mitochondria which consumes oxygen.
Normally, one pro-erythroblast gives — Erythrocytes.
In a case where less are being produced due to a reduction in DNA replication within the dividing cell stages, a person may develop —
16.
Macrocytic/Megaloblastic Anemia.
— is a type of maturation process where:
(i) The cytoplasm grows bigger and more hemoglobinized.
(ii) The nucleus becomes smaller.
Cytoplasmic Nuclear Synchrony
Less erythrocytes with larger than normal sizes being produced is a feature of —
Macrocytic Anemia
In Nuclear Cytoplasmic Asynchrony:
(i) The cytoplasm grows — and — hemoglobinized.
(ii) The nucleus — due to — DNA replication.
(i) bigger, more.
(ii) doesn’t shrink, no.
In Microcytic Anemia, the problem experienced by the dividing erythrocyte precursors is one of —.
Protein synthesis (Hemoglobin, to be specific).
In what type of anemia do the mature erythrocytes have smaller sizes and far more numbers than usual?
Microcytic Anemia.
