Hemapoeisis

Question 1

In the foetus, blood production begins in Month —.

Answer 1

Four (4)

Question 2

Between Weeks 1 and 3 of intrauterine life, blood supply to the foetus is mediated by the — from the —

Answer 2

Placental route, mother

Question 3

The liver begins hemapoeisis primordially from — and continues on till —.

Answer 3

The fourth week, the fourth month

Question 4

Hemapoeisis begins in the Spleen.

Answer 4

False

Question 5

The production of blood in foetal life begins with the spleen from weeks three to four.

Answer 5

False. It begins in the Yolk sac in that period.

Question 6

In foetal development, Hemapoeisis occurs first in the liver and then in the spleen.

Answer 6

True

Question 7

Production of blood in the marrow of long bones such as the clavicle ends in Year 2 after birth.

Answer 7

False

Question 8

Production of blood in the marrow of long bones such as the clavicle ends in Year 18 after birth.

Answer 8

True

Question 9

Hemapoeisis persists in the Basicranium throughout life.

Answer 9

True

Question 10

The vertebral column, shoulder girdle, basicranium, ribcage and — are examples of regions with lifelong hemapoeisis.

Answer 10

Pelvic girdle

Question 11

Blood production in the radius and ulna continue on till about 24 years post-natally.

Answer 11

False. They are long bones, so hemapoeisis ends in Year 18 for them.

Question 12

— is the tissue that occupies the space between opposing endosteal surfaces of a cavity bone.

Answer 12

Bone Marrow

Question 13

The bone has a nutrient foramina that leads into a nutrient canal where the nutrient artery carrying its systemic blood supply branches out into —

Answer 13

Medullary Arteries

Question 14

The nutrient artery becomes the — in the medullary cavity

Answer 14

Medullary Artery

Question 15

Within the Bone cortex, a — canal bearing capillary derivatives of the — arteries bears blood supply to the cortical cells.

Answer 15

Harvesian, transverse

Question 16

The transverse arteries get into the bone cortex by:

Answer 16

Piercing through the bone’s endosteal surface

Question 17

— eventually form the Bone Marrow Sinusoids

Answer 17

The Harvesian Capillaries

Question 18

The immediate route for venous drainage of the bone marrow is from the — to the —

Answer 18

Medullary vein, emissary vein

Question 19

— is the site for hemapoeisis in the bone marrow.

Answer 19

Hemapoeitic Inductive Microenvironment

Question 20

The bone marrow site containing the materials required for hemapoeisis is found in the —

Answer 20

Bone Marrow Sinusoids

Question 21

In the blood supply to the Bone Marrow:
(i) The — coming from the systemic circulation passes through the — and runs through the — to become the bone’s medullary artery.
(ii) Within the bone cavity, the Medullary Artery gives rise to the Harvesian Capillaries.
(iii) The — arteries coming from the Medullary artery pierce the bone’s endosteal surface to enter the cortex. There, they run through the — and become the capillaries that supply the cortical cells.

Answer 21

(i) Nutrient Artery, Nutrient foramina, Nutrient canal.
(ii) False. The Harvesian Capillaries arise from the Transverse Arteries.
(iii) Transverse Arteries, Harvesian canal.

Question 22

The Harvesian capillaries push through the cortex and out into the endosteum to form the pouch containing the HIM matrix.

Answer 22

True. The pouch mentioned refers to the sinusoids.

Question 23

Mesenchymal cells surround the luminal surface of the HIM

Answer 23

False. The luminal surface is lined by endothelial cells.

Question 24

Fibroblasts are examples of reticulate cells of the HIM’s abluminal matrix.

Answer 24

False. Fibroblasts are abluminal cells, but not reticulate.

Question 25

The production of Type II collagen fibers is a function of the stroma cells of the HIM matrix.

Answer 25

False. Stroma and fibroblast cells produce Types I, III and IV collagen fibers.

Question 26

— are cement tissue secreted into the HIM matrix by the cells of the abluminal surface. KEY: It’s the umbrella name.

Answer 26

Aminoglycans

Question 27

Chondroitin (IV) sulfate, heparan sulfate, hyaluronic acid and darmatan are all examples of cement tissue

Answer 27

True

Question 28

The Granulocyte-Macrophage Colony Stimulating Factor is secreted by the macrophages lining the abluminal surface alone.

Answer 28

False. It is secreted by ALL the immune cells of the abluminal surface (including the fibroblasts).

Question 29

Endoglin, laminin and tenacin are proteins responsible for preventing the premature ejection of immature hematopoeitic cells into sites for secondary development (eg. the spleen).

Answer 29

True

Question 30

Tenacin is supported by - - - - -nectin, haemo- - - - - - and vitronectin in the execution of its function within the HIM matrix.

Answer 30

Fibro, nectin