Megakaryocytopoeisis Flashcards
(13 cards)
— is the process by which platelets are formed.
Megakaryocytopoeisis
The primary precursor cells of the megakaryocytes are the —.
Megakaryoblasts.
Megakaryocytes can be differentiated from Lymphocytes by their — size and their ability to stain for —
slightly bigger, platelet-derived growth factor
A type of mitotic division in which the nucleus duplicates without the cell dividing due to a failure of the mitotic telophase is called?
Endonuclear re-duplication
In Endonuclear reduplication, the nucleus bears multiple replicated nuclei within it.
True.
In Endonuclear reduplication, the cytoplasm increases with an increase in the cell’s N-stage.
True.
The conversion of Megakaryoblasts to megakaryocyte can go as high as 7 nuclear re-duplications, resulting in a 128-N Megakaryocyte.
True.
The platelets are fragmentations of the nuclei of the mature megakaryocytes.
False. They are fragmentations of the cytoplasm.
The process by which endothelial cells are stripped off, injured or destroyed is known as?
Endothelial cell denudation
The two main functions of the platelets are:
(i) They seal injured blood vessels.
(ii) They replace denuded endothelial cells.
Platelets — to subendothelial structures when their — receptors join with the Von Willebrand factors present on the subendothelial structures.
adhere, Platelet Glycoprotein Ib. (This is the process of Platelet Adhesion).
The platelet’s — receptor, along with —, allows for platelet aggregation which is the process by which:
- Glycoprotein IIb-IIIa, fibrinogen.
- Platelets lie directly over each other to form a clot.
A disease stemming from a deficiency in Platelet Glycoprotein IIb-IIIa that presents with epistaxis (nose bleeds) and gingivitis (bleeding gums) is:
Glanzmann’s Disease/Glanzmann Thrombasthenia.
