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Flashcards in Estrogens Deck (7)
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1
Q

Estrogens & Progestins

A
  • promotes female maturation
  • help regulate ongoing activity of female reproductive organs
  • estrogens affect bone mineralization and lipid metabolism
2
Q

Principal Endogenous Estrogen

A

estradiol

3
Q

Therapeutic Uses for Estrogen

A
  • hormone therapy after menopause
  • female hypogonadism
  • acne
4
Q

Routes of administration for Estrogen

A
  • oral
  • transdermal
  • intravaginal
  • parenteral
5
Q

Metabolic Actions of Estrogen

A
  • positive effect on bone mass
  • favorable effects on cholesterol levels
  • blood coagulation
6
Q

Adverse Effects of Estrogen

A
  • endometrial hyperplasia and carcinoma
  • promotes growth of existing breast cancer
  • ovarian cancer
  • cardiovascular events
  • Nausea
  • adverse effects from use during pregnancy
7
Q

Selective Estrogen Receptor Modulators (SERMs)

A
  • activate in some tissues and block estrogen receptors selectively in others
  • developed to provide benefits of estrogen while avoiding the drawbacks
  • includes tamoxifen and raloxifene