ETP- hematology quiz

Question 1

Which of the following are NOT part of the factors that increase the risk of pathological clots, known as Virchow’s triad?

Question 1 Answer

a.
Stasis of blood flow

b.
Damaged vascular endothelium

c.
Hypercalcemia

d.
Hypercoagulability

Answer 1

c.
Hypercalcemia

Question 2

A 42-year-old woman presents with fever, fatigue, and widely disseminated purpura. On neurological testing she reports that her left hand feels “clumsy” and she has difficulty with rapid alternating movements and point-to-point movements with her left hand. Serum laboratory analysis is notable for elevated creatinine and BUN as well as thrombocytopenia and a normocytic, normochromic anemia. The hematologist confirms a diagnosis of thrombotic thrombocytopenic purpura (TTP).

What enzyme is deficient in most patients with TTP?

Question 2 Answer

a.
Glucose-6 phosphate dehydrogenase

b.
ADAMTS13

c.
Glutathione reductase

d.
Ankyrin

Answer 2

b.
ADAMTS13

Question 3

A 65-year-old female presents with fatigue, palpitations, and glossitis. Laboratory tests reveal macrocytic anemia and elevated serum homocysteine levels. Recently, she has also begun to exhibit cognitive impairment, including memory loss.

Elevated homocysteine levels can be reduced by conversion of homocysteine to cysteine. Which of the following vitamins is directly involved in the conversion of homocysteine to cysteine?

Question 3 Answer

a.
B5

b.
B9

c.
B6

d.
B3

Answer 3

c.
B6

Question 4

A 25-year-old man is incidentally found to be anemic when his bloodwork is done for a physical required by his occupation. He has no symptoms of fatigue or exercise intolerance, and no remarkable findings on physical exam. CBC reveals a mild microcytic hypochromic anemia with a red cell distribution width and reticulocyte count within normal limits. He is diagnosed by the hematologist with thalassemia.

What type of hemoglobin is found in most adult red blood cells?

Question 4 Answer

a.
Hemoglobin A2

b.
Hemoglobin C

c.
Hemoglobin beta

d.
Hemoglobin A

Answer 4

d.
Hemoglobin A

Question 5

A 72-year-old man presents with insidious onset of fatigue over the past year. He has also recently noticed that his stools have become progressively darker and they tend to “stick” to the toilet bowl after a bowel movement. A CBC reveals microcytic anemia with a decreased hematocrit and increased red cell distribution width as well as a decreased reticulocyte count. The patient’s serum iron is low.

Choose the TRUE statement regarding hepcidin and iron physiology.

Question 5 Answer

a.
Hepcidin increases the production of transferrin by the liver

b.
Hepcidin increases the rate of reduction of Fe+3 in the intestinal lumen

c.
Hepcidin is released by the liver in response to low iron levels in the blood

d.
Hepcidin blocks ferroportin

Answer 5

d.
Hepcidin blocks ferroportin