Flashcards in Exam #01a - Intro to CNS Pharmacology Deck (23):
Which part of the brain is associated with memory?
Hippocampus, part of the limbic system)
Drugs affecting BP, HR, and RR would affect which part of the brain?
Midbrain and brainstem
Which part of the brain is associated with higher thought processes including consequences?
What are the (2) supportive cells of the brain?
True or False - any agent that slows or blocks the axonal electrical conduction will affect sensation, perception, and behavior?
True or False - the ability of an agent to affect CNS function depends on its ability to cross or mediate an effect across the BBB?
What is the primary cellular mechanism by which plasma protein constituents and macromolecules pass through the cerebrovascular endothelium (BBB)?
Pinocytosis (transendothelial vesicular transport)
List the (6) drug-sensitive sites of drug action?
1. excitable membrane
2. presynaptic or postsynaptic receptors
3. synthesis and storage of transmitters
4. uptake sites
5. cytoplasmic organelles
True or False - both the frequency and magnitude of neurons firing can be altered by drugs?
False - ONLY the FREQUENCY can be changed, magnitude (AP) cannot be changed
How do most drugs appear to act on the CNS?
by changing ion flow through transmembrane channels of nerve cells (LGIC's) --> ionotropic
What is the approximate resting transmembrane potention of a neuron?
What type of patient would benefit from a drug that causes a EPSP?
Patient whose neurons aren't firing as rapidly as needed. An EPSP means that an excitatory stimulus was given and now the next time a stimulus is applied, the neuron is more likely to reach threshold and produce an AP
What type of patient would benefit from a drug that causes a IPSP?
Patient with epilepsy whose neurons are firing uncontrollably. An IPSP hyperpolarizes (makes it more negative) a neuron making it less likely to reach threshold and fire
Many inputs arrive at a postsynaptic cell with each one carrying a potentially different signal. Which part of the postsynaptic neuron determines if the neuron actually produces an AP?
Hillock (trigger zone)
Name (2) excitatory amino acids?
1. glutamate (Glu)
2. aspartate (Asp)
Name (2) inhibitory amino acid?
1. GABA (gamma-aminobutyric acid)
2. glycine (Gly)
What % of neurons have AChRs? Of this %, are there more mAChRs (7TM GPCRs) or nAChR's (ligand-gated ion channels)?
NE receptors in the brain are responsible for many functions. Name (5)?
2. learning and memory
3. sleep/wake cycle
5. BP regulation
What are the (4) major NT receptors in the CNS?
What is the predominant catecholamine in the CNS?
DA is transmitted from one part of the brain to another by what (3) pathways? Indicate for each pathway what is controlled by it?
1. nigrostriatal (motor control)
2. mesolimbic (behavior)
3. hypthalamus-piuitary (hormone release)
Which NT is associated with sleep, mood, and emotion?