Exam #01e - GOUT Flashcards Preview

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Flashcards in Exam #01e - GOUT Deck (13):
1

This condition is defined as precipitation of uric acid in tissues and joints?

Gout

2

Uric acid is a product of BLANK metabolism?

purine metabolism

3

What (2) conditions must be met for a patient to have uric acid crystalize in joints causing gout?

1. concentration of uric acid must be high enough
2. pH must be low enough

4

True or False - usually most uric acid is reabsorbed by the kidneys?

True

5

Name (2) general causes of hyperuricemia?

1. increased uric acid production
2. decreased renal clearance

6

True or False - hyperuricemia is only a problem if uric acid starts to precipitate?

True

7

What are the (3) treatment strategies of gout?

1. reduce inflammation and pain during acute attack
2. increase renal excretion
3. decrease uric acid production

8

What (4) medications can be given to reduce inflammation and pain of acute gout attack?

1. NSAIDs
2. analgesics (pain only)
3. glucocorticoids (intra-articular)
4. colchicine

9

Why wouldn't APAP be a good drug to treat acute gout attack?

It has no anti-inflammatory activity

10

What (2) drugs are given to treat gout by increasing renal excretion of uric acid by competing with uric acid for reabsorption in kidney PCT?

1. probenecid
2. sulfinpyrazone

11

What (2) drugs are given as prophylaxis for gout to decrease production of uric acid?

1. allopurinol
2. febuxostat

12

Which (2) drugs are xanthine oxidase inhibitors?

1. allopurinol
2. febuxostat

13

What are drugs that accelerate renal excretion of uric acid called? Give (2) examples?

Uricosurics

1. probenecid
2. sulfinpyrazone