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Flashcards in Exam 1 Deck (42)
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1

What is the only aa that has buffering properties

Histidine, sits at ph 6-7

2

Tryptophan is a precursor to what molecule

Serotonin

3

What molecule is a major player in tryptophan being able to cross the blood brain barrier

Insulin, generally from response to high carb diet

4

What is the primary excitatory neurotransmitter of the CNS

Glutamate

5

What functions is glutamate a key player in

Pain sensation
Neuronal plasticity
Central sensitization

6

What does the primary structure of a protein determine

Shape AND function

7

What is the importance of substance p

It is a neuropeptide that is co- released with glutamate to create a greater sense of pain and injury in the system.

8

What number of aa corresponds with a polypeptide

10-20 aa

9

What number of aa corresponds to proteins

>20 aa

10

What are the functional classes of proteins

Enzymes
Transport
Mechanical support
Contractile
Control and signaling

11

What is the cause of sicke cell anemia

A non conservative change of a Hb protein of glutamate, for valine

12

What aa h-bond together in an alpha helix

1st and 5th

13

What is average distance between turns when h-bonding occurs in an alpha helix

3.6aa/ turn

14

Why is the anti parallel nature of beta sheets stronger than a parallel structure

The h bonds are closer together in a anti parallel structure, while there is a slightly larger distance between the bonds in a parallel structure, thus making the bonds weaker

15

Where is beta sheeting often found

Inside the cell, and often pulls proteins together

16

Which secondary structure makes up half of the globular proteins

Beta sheeting

17

What is the predominant aa in the collagen triple helix

Glycine- approx every 3rd aa in the chain

18

What is the basic unit of collagen

Tropocollagen

19

What is the basic structure of tropocollagen

3 separate peptide chains held together by interchain h bonds

20

A polyproline strand will form what structure

A TRIPLE helix

21

What factor is required for proper collagen formation

Vitamin c, lack of will lead to scurvy

22

What causes cross linking in collagen

Losing residues
Larger amounts cause aging
Lack of cross linking causes stretchy skin

23

What is the specific structure of protein due to

Hydrophobic bonding
Specific side chain interactions

24

What is the strongest 3* structure interactions

Disulfide bridges

25

What is the weakest 3* interaction

Van der waals forces

26

How does urea denature a protein

Out-competes for h bonding of protein structures at all levels

27

How many bonds are needed for a biuret reaction to occur

At least 2 peptide bonds

28

What does hydrolysis and proteases do to protein

Denatures by breaking peptide bonds

29

How can you separate out individual proteins

Gel electrophoresis

30

What molecule musts specifically be present for o2 to bind a Hb

Fe2+
Must be present in the heme group of Hb