Exam 1 - Fall Flashcards
(166 cards)
what is the most common form of arthritis?
what does it involve?
OA
- degen of articular cartilage
- subchondral sclerosis
- hypertropic of bone & joints (osteophytes)
- synovial membral & joint calsule alterations
articular cartilage
chondrocytes
synth type II collagen for ECM
role: reduce joint friction & absorb shock

Activation of chondrocytes from trauma will cause the chondrocytes to release _______
leads to shift towards what type(s) of collagen?
release proinflamm cytokines (TNFalpha)
shift from type II collagen –> type I & III collagen and shorter proteoglycans
primary defect in OA is…
what processes?
loss of articular cartilage
(1) SA flakes off
(2) longitudinal fissures (fibrillation)
(3) thin –> absent –> unprotected subchondral bone –> sclerotic
(4) cysts
what forms as articular cartilage erodes?
osteophytes: alteral coutour & anatomy
risk factors of OA (5)
- age
- repetitive trauma
- obesity
- mineral deposition
- systemic hormones
signs & symptoms of OA
- morning stiffness <30min
- stiffness after effort (most painful @ night)
- limited ROM
- bony crepitus:
- bouchards @ PIP
- heberdens @ DIP

OA Tx
non-rx:
- wt loss, exercise, PT, muscle strengthening
rx
- analgesics, NSAIDS, intra-articular steriods & hyaluronic acid
sx
glucasamine/chondrotin
RA
chronic systemic inflammatory disorder: infiltration of immune cells
bilateral
pathophys of RA
(1) injury to synovial microvasc - occlusion and swelling
(2) infilt by lymphocytes and mac-phages
(3) hypertrophy & pannus formation
(4) destruction of periarticular bone & cartilage
RA etiology
shared epitotpe of 5aa seq motif in HLA-DR beta chain
cigarette smoke
infections
signs & symptoms of RA
prolonged early morning stiffness
symmetrical joint swelling
hands & feet joints
ulnar deviation
(+) RF factor
subQ nodules
what OMM technique is C/I in RA?
HVLA of upper c-spine due to ligamentous instability –> possible subluxation of dens into SC
physical findings of RA (3)

systemic manifestations of RA
interstitial lung disease
systemic vasculitis
pericarditis
anemia
felty’s syndrome
RA Tx
DMARSD: methotrxate, plaqueil
NSAIDS
etanercept
steroids
PT
firbromyalia
generalized pain - “hurt all over” - soft tissue pain
muscles feels “doughy”
fibromyalgia prevalence
mean age: 45
women > men
(1) low income, (2) unmarried, (3) smokers, (4) obese, (5) with other rheumatic disorders
FM- NS dysfx
- sleep distrubance: alpha wave intrusion in stage 4 (delta wave) –> decreased GH
- hypoT-pituitary-adrenal axis: low cortisol, high substance P due to chronic stress, low neuroT (serotonin, dopamine, noradrenalin)
- SNS dysfx
- abdormal pain processing
- hyperalgesia
- allodynia: non-noxious stimuli interpreted as painful
- decreased blood flow in pain inhib regions of brain, like thalamus
exam of fibromyalgia pts (4)
neuro = normal
tenderpoint = local without referral
doughly muscles
hypermobility
5 models of ostephatic medicine
- Biomechanical Model
- Respiratory/Circulatory Model
- Neurological Model
- Metabolic Energy Model
- Behavioral Model
with foot on ground: last 30 degrees of knee extension is accompanied by:
with foot off ground: last 30 degrees of knee extension is accompanied by:
on ground: medial femoral rotation
off ground: onjoint lateral tibial rotation
what happens to FM pts after HVLA
prone to painful flares
ME concept
golgi tendon: prevent too much tension
afferent: 1b –> dorsal horn
efferent: (-) alpha motor N –> relax M






































