Exam 1 - HIV Infection Flashcards
(46 cards)
What is the term that describes an indirect reflection of the number productively infected cells in the body as a whole?
Viral RNA
-A proportion between plasma viral RNA and the amount of virus in the fixed lymphoid tissues
T/F: HIV RNA levels appear more predictive of progression of HIV than CD4+ counts.
TRUE
Name the different utilities of HIV RNA assays.
- Assessing baseline status in newly diagnosed HIV patient
- Assessing response to therapy
- Assessing development of resistance to current therapy
- Reductions in plasma viremia correlates with increased CD4+ cells and AIDS-free survival
According to Dr. Destache, how long does it take to reach a non-detectable level/load?
~4-6 months for a viral load of 20
When should you measure plasma HIV RNA?
In all HIV-1 infected patients at baseline and on a regular basis thereafter
What is the minimal change in viral load considered to be statistically significant?
A threefold or 0.5 log10 copies/mL change
What is the optimal viral suppression generally defined as?
A viral load below the level of detection (<200 copies/mL)
With Antiretroviral regimen, when is viral suppression achieved?
In 12-24 weeks viral suppression will be achieved
When should you monitor plasma viral load?
- At initiation OR change in therapy (within 2-4 weeks)
- In virologically suppressed patients in whom therapy was modified because of drug toxicity or regimen simplification
- In patients on a stable ARV regimen (repeat viral load Q3-4 months OR as clinically indicated - can extend interval to Q6 months for adherent patients with suppressed viral loads for more than 2-3 years and whose clinical and immunologic status is stable)
- Monitor in patients with a sub-optimal response to therapy (those that cannot get to un-dectable level)
What are the treatment goals for HIV treatment?
- Reduce HIV-associated morbidity and prolong the duration and quality of survival
- Restore and preserve immunologic function
- Maximally and durably suppress plasma HIV viral load
- Prevent HIV transmission
What are the four questions that need answers for HIV therapy?
1) When to initiate therapy?
2) Which type of drugs to use?
3) When to change therapy?
4) Which drugs to use when changing therapy?
T/F: Mother-to-child transmission of HIV does not occur.
FALSE - mother-to-child transmission of HIV does occur
T/F: For the most part, everyone gets 2 NRTIs.
TRUE
Cobicistat is a _____ for Elvitegravir.
Cobicistat is a BOOSTER for Elvitegravir.
What is the brand name for the following combination of drugs:
Efavirenz + Tenofovir disoproxil + Emtricitabine
Atripla
What are the 3 drugs in Atripla?
1) Efavirenz
2) Tenofovir disoproxil
3) Emtricitabine
What three drugs are in Biktarvy?
1) Bictegravir
2) Tenofovir alafenamide
3) Emtricitabine
What is the brand name of the drug that has the following combination:
Bictegravir + Tenofovir alafenamide + Emtricitabine
Biktarvy
What 2 drugs are included in Cabenuva?
1) Cabotegravir
2) Rilpivirine
What is the brand name of the following combination:
Cabotegravir + Rilpivirine
Cabenuva
What 3 drugs are included in Complera?
1) Rilpivirine
2) Tenofovir disoproxil
3) Emtricitabine
What is the brand name of the following combination of drugs:
Rilpivirine + Tenofovir disoproxil + Emtricitabine
Complera
What 3 drugs are included in Delstrigo?
1) Doravirine
2) Tenofovir disoproxil
3) Lamivudine
What is the brand name for the following combination of drugs:
Doravirine + Tenofovir disoproxil + Lamivudine
Delstrigo
