Final Exam (Dr. R Dull - 10 points)

Question 1

Name the 9 persons at HIGH risk of complications from Influenza that should be considered for antiviral therapy.

Answer 1

1) Age <5 years OR >65 years
2) Pregnancy or postpartum (within 2 weeks of birth)
3) Chronic pulmonary, cardiac, or kidney disease
4) Immunosuppressive conditions
5) Sickle cell disease, Thalassemia
6) Neurologic disorders (stroke, seizures, cognitive impairment)
7) Residents of nursing homes/LTC facilities
8) American Indian/Alaska Native
9) Morbid obesity (BMI >40)

Question 2

Name the 5 higher infection risk immunosuppressive conditions that should be considered for antiviral therapy.

Answer 2

1) Bone marrow transplant recipient (allogenic) - from a donor
2) Lymphoma, Leukemia, Myeloma
3) AIDS with low CD4 cell count
4) Functional or anatomical asplenia - spleen issues
5) Severe combined immunodeficiency - cogenital disease

Question 3

Name the 3 intermediate infection risk immunosuppressive conditions that should be considered for antiviral therapy.

Answer 3

1) Solid tumors
2) HIV with or without AIDS - AIDS with adequate CD4 cell count
3) Solid organ transplant recipients

Question 4

Name the 3 lower infection risk immunosuppressive conditions that should be considered for antiviral therapy.

Answer 4

1) Long-term use of systemic corticosteroids
2) Autoimmune disorders (i.e., RA)
3) DM

Question 5

Name the 3 persons that are at HIGH risk of severe COVID-19 (other than the ones listed for Influenza).

Answer 5

1) Only children who are immunosuppressed or have chronic conditions
2) Lower BMI threshold (BMI >25)
3) Mental health disorders (including depression) and substance use disorders

Question 6

Which 2 Neuraminidase inhibitors require renal dose adjustment?

Answer 6

1) Oseltamivir

2) Peramivir

Question 7

T/F: Zanamivir does not require renal dose adjustment.

Answer 7

TRUE

Question 8

T/F: Janus Kinase Inhibitors (JAK) require renal dose adjustment.

Answer 8

TRUE

Question 9

Which of the JAK inhibitors is preferred in severe renal impairment?

Answer 9

Tocilizumab

Question 10

T/F: Acyclovir/Valacyclovir do not require renal dose adjustment.

Answer 10

FALSE - renal dose adjustment required with Acyclovir/Valacyclovir