Exam 1 - Tuberculosis (8 points) Flashcards

(50 cards)

1
Q

What bacterium causes Tuberculosis?

A

Mycobacterium tuberculosis, an aerobic, acid-fast bacilli

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2
Q

Describe the bacterium Mycobacterium tuberculosis.

A

It is an aerobic, acid-fast bacilli

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3
Q

T/F: Tuberculosis is a leading killer in patients with HIV.

A

TRUE

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4
Q

Tuberculosis presents as either ____ or _____ disease.

A

Tuberculosis presents as either ACTIVE or LATENT disease.

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5
Q

Define Latent Disease.

A

Absence of symptoms (active disease) but test positively on skin testing

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6
Q

What area of the body does Tuberculosis infect?

A

Predominately the lungs, but can infect any organ of the body

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7
Q

How is Tuberculosis spread?

A

By airborne particles (droplet nuclei) from infected individuals that are inhaled

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8
Q

Name the three risk factors for TB.

A

1) Non-US born higher than US born
2) Homelessness
3) HIV

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9
Q

T/F: Latent disease TB is the most common form of TB.

A

TRUE

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10
Q

List the characteristics of Latent TB.

A
  • Asymptomatic
  • Can’t transmit to others
  • Will have a positive TB skin test
  • May progress to ACTIVE disease in the absence of preventative treatment
  • May progress to ACTIVE disease if patient becomes immunosuppressed from disease or medications
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11
Q

T/F: You cannot be latent disease TB your entire life.

A

FALSE - you can be latent your entire life

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12
Q

T/F: In latent TB you cannot transmit to anyone else.

A

TRUE - can’t transmit to others in latent tuberculosis

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13
Q

T/F: In latent TB patients will have a negative TB skin test.

A

FALSE - in latent tuberculosis patients will have a positive TB skin test

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14
Q

Name the five categories of patients at risk for progression to active disease.

A

1) HIV disease
2) Recent infection (last two years)
3) Babies and young children
4) Elderly
5) Untreated

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15
Q

Name the typical clinical presentations (s/s) for active disease TB.

A
  • Fever
  • Night sweats
  • Weight loss
  • Fatigue
  • Productive cough
  • Hemoptysis
  • Elevated lymphocyte count
  • Thrombocytosis
  • Cavitary lesions on x-ray, commonly affecting the upper lobes
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16
Q

Name the atypical clinical presentations (s/s) of active disease TB.

A
  • Lymphadenopathy
  • HA
  • Seizures
  • Confusion
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17
Q

T/F: A progressive primary disease spreads beyond the lungs with the initial infection.

A

TRUE

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18
Q

T/F: A progressive primary disease also develops a latent period.

A

FALSE - progressive primary disease does not develop a latency period

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19
Q

What are the 3 risk factors for developing progressive primary disease?

A

1) Children
2) Elderly
3) Immunocompromised

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20
Q

How do we screen/diagnose TB?

A

Skin testing (Mantoux, PPD)

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21
Q

T/F: The skin testing for TB screening does not differentiate latent from active disease.

22
Q

How many unit are injected intradermally for the TB skin test?

A

5 tuberculin units

23
Q

Positive responders should ______ receive the skin test again.

A

Positive responders should NEVER receive the skin test again.

24
Q

What is the name of the TB diagnostic skin test?

A

Manatoux, PPD

25
Aside from the Mantoux, PPD skin test, what are three other additional tests for Tb?
1) Interferon gamma release test 2) QuantiFERON-Tb Gold test - MOST COMMON 3) T-Spot Tb test
26
T/F: All of the tests available to diagnose Tb can differentiate latent from active infection.
FALSE - None of the tests can differentiate latent from active infection
27
What is the "boost effect?"
When a patient has been exposed, have latent disease and their immunogenicity has worn off -The additional tests for Tb are not subject to "boost effect"
28
Name the three tests that test whole blood for antigens.
1) Interferon-gamma 2) Quantiferon 3) T-Spot test
29
Who should be tested for Tb?
Moderate risk patients who are under 65 years of age
30
T/F: Moderate risk patients, less than 65 years of age should be tested for Tb.
TRUE
31
Who are considered "moderate risk patients" that should be tested for Tb?
1) DM | 2) Receiving systemic glucocorticoids (>15 mg/day for >1 month)
32
What three ways is diagnosis of patients suspected of active disease conducted?
1) Chest X-ray 2) Sputum 3) Bronchial lavage or biopsy
33
Name the indications for a bronchial lavage or biopsy.
- Negative sputum smear | - Unable to produce sputum
34
What diagnostic procedure can you perform on a patient suspected of active disease if they cannot do a sputum test?
Bronchial lavage or biopsy
35
Name the selected indications for treatment of LTBI (latent disease).
- Individuals less than 50 years of age - Individuals 50-65 years of age who are at moderate to high risk of reactivation to active disease (immunosuppressed patients - i.e., HIV, chemo, DMARDs for RA, etc.) - Individuals >65 who are at high risk of reactivation to active disease
36
Treatment of Latent Tuberculosis -- Standard Regimen:
PREFERRED REGIMENS -Isoniazid (INH) + Rifapentine for adults and children >2 years of age once weekly for 12 weeks OR -Rifampin daily for 3-4 months (HIV negative) ALTERNATIVES -INH daily for 6-9 months
37
What is the alternative treatment for latent tuberculosis?
INH daily for 6-9 months
38
What is the preferred regimen for treatment of latent tuberculosis?
Isoniazid (INH) + Rifapentine for adults and children >2 years of age once weekly for 12 weeks OR Rifampin daily for 3-4 months (HIV negative)
39
What are the benefits to having INH and Rifapentine in combination?
They have shown a less incidence of liver toxicity and a shorter duration
40
Name the side effects of Isoniazid.
1) Rash 2) Agranulocytosis, anemia, thrombocytopenia 3) Peripheral neuropathy
41
What is the prevention treatment for peripheral neuropathy that can occur when taking Isoniazid?
25-50 mg pyridoxine (vitamin B6) po qd
42
Peripheral neuropathy interferes with _______ _________.
Peripheral neuropathy interferes with PYRIDOXINE METABOLISM.
43
Another name for vitamin B6 is?
Pyridoxine
44
How is Isoniazid metabolized?
Isoniazid is metabolized by acetylation in the liver
45
What two ethnicity's are fast acetylators of Isoniazid?
Asian Eskimo
46
What two ethnicity's are slow acetylators of Isoniazid?
African Americans Caucasians
47
What is the half-life of Isoniazid in fast acetylators?
<2 hours
48
What is the half-life of Isoniazid in slow acetylators?
3-4 hours
49
Which type of acetylators (fast or slow) of Isoniazid are at greater risk for side effects such as peripheral neuropathy?
SLOW acetylators
50
Who is at risk of hepatotoxicity (increased liver enzymes) when taking Isoniazid?
- Elderly - Pregnant or post partum - Possibly slow acetylators