exam 1 MOA Flashcards
(18 cards)
inhibits liver gluconeogensis
increases insulin sensitivity
decreases intestinal glucose absorption
metformin
blocks intestinal hydrolysis of oligosaccharides to glucose
decreases digestion/absorption of dietary carbs
inhibits pancreatic alpha-amylase
alpha glucosidase inhibitors
increase incretin (GLP1 and GIP) half lives by preventing their degradation
DPP4 inhibitors
resistance to DPP4 mediated degradation
prolonged half life from albumin binding and DPP4 resistance
stimulate insulin release in glucose dependent manner
GLP1
glucose independent insulin secretion
bind to K-ATP channels independently of glucose and ATP
Ca influx
sulfonylurea
stimulates insulin secretion through SUR1 interactions
meglitinides
PPAR-y agonists
increases insulin sensitivity
TZD
blocks SGLT2
increases urine glucose excretion
lowers glucose independently of insulin
SGLT2-i
prevents VEGF from binding to receptors and stimulating angiogenesis (endothelial proliferation)
VEGF inhibitors
inhibits leukocyte infiltration, edema, capillary dilation, proliferation and leakiness, collagen and fibrin deposition, scar formation
corticosteroid
decrease Ang 2 levels
ACE
inhibits Ang 2 receptor type 1 (AT-1)
vasodilation, decreased aldosterone
decreased glomerular pressure and microalbuminuria
ARB
decreases heart rate, BP, sympathetic tone, kidney renin release
beta blockers
heart- inhibits cardiac smooth muscle contraction
vascular smooth muscle- relaxation, decreases vascular resistance and systemic BP
CCB
inhibits sodium and chloride resorption in kidneys, increasing water excretion
renal vasodilation and increased blood flow
diuretics
selective serotonin and NE reuptake inhibitor
duloxetine
Mu opioid receptor agonists
NE reuptake inhibitor
tapentadol
