Exam 10: Marijuana and Stuff Flashcards Preview

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Flashcards in Exam 10: Marijuana and Stuff Deck (31)
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1
Q

Hashish

A

Marijuana plant resin with super high TCH concentration

2
Q

K-2 and Spice

A

Synthetic Marijuana

3
Q

Pharmacokinetics of Marijuana

A

Highly lipid soluble

Accumulates in fat and is slowly released over time

4
Q

High dose effects of marijuana

A

Paranoia, hallucinations, psychosis

5
Q

Marijuana cardiovascular effects

A

Tachycardia

Postural hypotension

6
Q

How might marijuana help with glaucoma treatment?

A

decrease intraocular pressure

7
Q

How might marijuana help cancer patients?

A

Inhibition of vomiting reflex (antiemetic during chemo)

8
Q

Marijuana toxicities

A
  1. Immunosuppression
  2. Lower testosterone
  3. Teratogenic
  4. Lung damage
9
Q

Medical uses of marijuana (3)

A
  1. Prevention of nausea during chemotherapy
  2. Prevention of “wasting” in AIDs
  3. Glaucoma/asthma (data shows that it doesnt really work)
10
Q

What is used in native american ceremonies to get high?

A

Salvia

11
Q

Salvia mechanism

A

Salvinorin A is an agonist at kappa opioid receptors and D2 dopamine receptors

12
Q

Salvia effects

A

Hallucinogen (different from other hallucinogens somehow)

13
Q

Krakom

A

Plant from Thailand that is a stimulant/pain releiver

14
Q

Krakom mechanism

A

Similar to opioids, but different…

15
Q

Krakom uses

A

“Legal opioid”
being abused
some use it for pain control or opioid withdrawal

16
Q

What neurotransmitter disturbance is seen in Alzheimer’s?

A

Decreased ACh in the nucleus basalts of Meynert

17
Q

What drugs can be used to treat Alzheimer’s neurotransmitter disturbance?

A

Acetylcholinesterase inhibitors
Rivastigmine
Donepezil

18
Q

How effective are acetylcholinesterase inhibitors in treating Alzheimers?

A

Modest improvement in cognitive function in some, not much in other.
Do not slow the progress of the disease

19
Q

Side effects of donepezil, rivastigmine?

A

Muscarinic stuff… (leaky)

20
Q

Which acetylcholinesterase inhibitor causes less side effects?

A

Donepezil

21
Q

Memantine use

A

Alzheimers

22
Q

Memantine mechanism

A

NMDA antagonist

also blocks excitatory glutamate at NDMA receptors in the hippocampus and frontal cortex

23
Q

how do vitamin E, seligiline, and deprenyl help with alzheimers

A

antioxidant properties

controversial aka probably complete bullshit

24
Q

What is the only drug that treats ALS?

A

Riluzole

25
Q

Riluzole mechanism

A

inhibits excitatory glutamate

26
Q

Mainstay drug of ADHD therapy

A

Methylphenidate

27
Q

adderall

A

d-amphetamine/d,l-amphetamine

reserved for patients who don’t respond to methylphenidate

28
Q

Adderall problem

A

Schedule II

can complicate prescribing

29
Q

Atomoxatine mechanism

A

inhibits NE reuptake

30
Q

Atomoxatine use

A

benefits ADHD patients who don’t respond well to or tolerate stimulants
not as effective in most people though

31
Q

Atomoxatine side effect

A

serious hepatotoxicity in some people