Exam 10: Marijuana and Stuff Flashcards Preview

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Flashcards in Exam 10: Marijuana and Stuff Deck (31):
1

Hashish

Marijuana plant resin with super high TCH concentration

2

K-2 and Spice

Synthetic Marijuana

3

Pharmacokinetics of Marijuana

Highly lipid soluble
Accumulates in fat and is slowly released over time

4

High dose effects of marijuana

Paranoia, hallucinations, psychosis

5

Marijuana cardiovascular effects

Tachycardia
Postural hypotension

6

How might marijuana help with glaucoma treatment?

decrease intraocular pressure

7

How might marijuana help cancer patients?

Inhibition of vomiting reflex (antiemetic during chemo)

8

Marijuana toxicities

1. Immunosuppression
2. Lower testosterone
3. Teratogenic
4. Lung damage

9

Medical uses of marijuana (3)

1. Prevention of nausea during chemotherapy
2. Prevention of "wasting" in AIDs
3. Glaucoma/asthma (data shows that it doesnt really work)

10

What is used in native american ceremonies to get high?

Salvia

11

Salvia mechanism

Salvinorin A is an agonist at kappa opioid receptors and D2 dopamine receptors

12

Salvia effects

Hallucinogen (different from other hallucinogens somehow)

13

Krakom

Plant from Thailand that is a stimulant/pain releiver

14

Krakom mechanism

Similar to opioids, but different...

15

Krakom uses

"Legal opioid"
being abused
some use it for pain control or opioid withdrawal

16

What neurotransmitter disturbance is seen in Alzheimer's?

Decreased ACh in the nucleus basalts of Meynert

17

What drugs can be used to treat Alzheimer's neurotransmitter disturbance?

Acetylcholinesterase inhibitors
Rivastigmine
Donepezil

18

How effective are acetylcholinesterase inhibitors in treating Alzheimers?

Modest improvement in cognitive function in some, not much in other.
Do not slow the progress of the disease

19

Side effects of donepezil, rivastigmine?

Muscarinic stuff... (leaky)

20

Which acetylcholinesterase inhibitor causes less side effects?

Donepezil

21

Memantine use

Alzheimers

22

Memantine mechanism

NMDA antagonist
also blocks excitatory glutamate at NDMA receptors in the hippocampus and frontal cortex

23

how do vitamin E, seligiline, and deprenyl help with alzheimers

antioxidant properties
(controversial aka probably complete bullshit)

24

What is the only drug that treats ALS?

Riluzole

25

Riluzole mechanism

inhibits excitatory glutamate

26

Mainstay drug of ADHD therapy

Methylphenidate

27

adderall

d-amphetamine/d,l-amphetamine
reserved for patients who don't respond to methylphenidate

28

Adderall problem

Schedule II
can complicate prescribing

29

Atomoxatine mechanism

inhibits NE reuptake

30

Atomoxatine use

benefits ADHD patients who don't respond well to or tolerate stimulants
not as effective in most people though

31

Atomoxatine side effect

serious hepatotoxicity in some people