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Flashcards in Exam 2 a Deck (168)
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1

characteristics of fungi cell walls

-Potential targets for anti-fungal therapy
*cell membranes can be potential targets too
-Gram positive
-Carbohydrate staining (for diagnosis)

2

fungi characteristics

1. cell wall
2. cell membrane
3. nuclear membrane
4. mitochondria
5. Capsules (some)-

3

fxn of a fungi cell capsule

prevents phagocytosis

4

types of fungi

1. yeast
2. molds
3. dimorphic

5

Single cells
Grow by budding (or binary fission)
Pasty colonies on* solid media

yeast

6

multicellular
filamentous – cylindrical tubules (hyphae)
colonies (“fuzzy” or “moldy”) grow above and below* surface of agar
elongate from their tips
spread by fragmentation and spores

Molds

7

Either yeast or mold - depends on conditions

dimorphic

8

clinical classificiation of fungi

1. superficial
2. mucocutaneous (Dermatophytosis)
3. subcutaneous
4. systemic-primary
5. systemic- opportunist

9

examples of ___ fungi:
Pityriasis versicolor
(Malassezia furfur)

superficial fungi

10

examples of ____ fungi:
Candida Skin, mucosa, nails
Dermatophytosis (Tinea)

mucocutaneous fungi

11

example _____ fungi:
Sporotrichosis

subcutaneous fungi

12

Examples of ____ fungi:
Coccidiodomyosis
Histoplasmosis
Blastomycosis
Cryptococcosis

systemic- primary fungi

13

examples of ____ fungi:
Candida
Aspergillus
Mucormycosis
Yeast (Torulopsis)

systemic- opportunist fungi

14

Malassezia furfur

yeast
Tinea versicolor
superficial fungi

15

-scaling white or brown patches (especially sternum/between scapulae)
-cosmetic concern (slight itching)
-Hair = black piedra

Malassezia furfur (Tinea versicolor)

16

lives on outer desquamating skin (tinea) or hair

superficial fungi

17

how do you diagnose Malassezia furfur (Tinea versicolor)

Clinical
KOH prep of skin scrapping under microscpope

18

Piedra

superficial nodules on hair
*associated with Malassezia furfur (Tinea versicolor)

19

treatment of Malassezia furfur (Tinea versicolor)

Selsun (selenium based shampoo)
topical antifungals (clotrimazole) for skin and hair

20

Fungemia in patients receiving IV lipids

mainly fever
culture with olive oil

*TINEA VERSICOLOR

21

Colonize and invades skin/hair - grows IN* upper layer of skin
-Involves scalp (t.capitis); body (t.corporis); “jock itch” (t.cruris); feet/hands; nails


Dermatophytosis

*broken off hair with inflamed underlying scalp

22

reservior of cutenous/dermatophytes fungi

universal- spreads between people and pets

23

Most people infected at some point in their life called "tinea" or "ringworm"

Dermatophytosis

24

kerion

boggy mass that is allegi rxn in scalp

*hallmark of Dermatophytosis

25

presents with:
erythematous, scaly, round lesions w/ papules and scale at the margin and clear in center
thickened, broken-off hairs
Kerion

Dermatophytosis

26

how to diagnose Dermatophytosis

clinical
KOH prep
Culture
UV lights up lesions from one species (Wood's lamp)

27

Most common fungal infection in young children

Dermatophytosis

28

80% of humans are colonized by age one month; spreads between people

Candida

*Commensal (disease only appears if host is altered "opportunistic infection" ie. immune compromised or antibiotics

29

adherent, white exudate in oral mucosa +/- pain; do not confuse with food residue

Thrush
(Mucocutaneous Candida)

30

inflamed; sharply defined margins with satellite lesions; itchy; in skin folds (moist areas)

skin
(Mucocutaneous Candida)