Exam 2: Major Proteins in DNA Replication Flashcards Preview

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Flashcards in Exam 2: Major Proteins in DNA Replication Deck (10)
1

helicase

moves along the fork unwinding dsDNA into two strands of ssDNA

2

SSBP

single-strand binding protein

keeps ssDNA strands apart

3

topoisomerases

type 1 and 2

eliminate excess supercoiling generated by unwinding

4

topoisomerase 1

nick, rotate, ligate

5

topoisomerase 2

double-strand break, pass through, rejoin

6

primase

makes short RNA primers on ssDNA strand

7

DNA polymerase 1

rips our RNA primer, puts in DNA, in steps of one nucleotide at a time

8

DNA polymerase 3

5'3' polymerase

synthesizes DNA starting at an RNA primer

9

ligase

closes nicks in the sugar-phosphate backbone of one ssDNA strand in dsDNA

10

telomerase

enzyme that restores full-length telomeres in the chromosomes of gametes

renews telomeres in stem cells when they divide