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Flashcards in Complementation Deck (23)
1

there can be many ___ at the same ___ and many ___ acting on the same ___

alleles, locus

loci, trait

2

+ means

wild-type

3

different alleles are indicated how?

superscripts

4

2 homozygous individuals w/ different recessive alleles at the same locus will...

have heterozygous offspring with a recessive phenotype

5

often mutations at different loci can give....

identical or nearly identical phenotypes

6

suppose you have 2 recessive mutant strains w/ same phenotype. they could be due to...

mutations at the same locus

2 different loci acting on the same trait

7

double heterozygote offspring

2 individuals with recessive homozygotes at different loci can fix each other

normal phenotype

8

how to tell if the mutation is caused by one locus or different loci?

cross them

9

offspring of the mutant phenotype caused by 2 mutations at the same locus...

will have the same mutant phenotype

10

offspring of the mutant phenotype caused by mutations at 2 different loci...

will be wild type

11

complementation

when 2 recessive homozygotes produce wild-type offspring

12

when complementation occurs how many loci are involved?

2

13

noncomplementation is when the offspring...

look like the recessive parents

14

alleles at the same locus are called

complementation group

15

complementation group

mutations that don't complement eachother

mutants lying within the same cistron (noncomplementation group)

16

mutant screen asks

how many different loci are involved when all these lines have the same phenotype?

17

how to do a mutant screen?

mutate many flies (make grandchildren homozygous by inbreeding)

keep looking for same recessive phenotype

18

pleiotropy

multiple traits caused by the same gene

one mutation w/ multiple effects

19

examples of pleiotropy

Waardenburg Syndrome

Nail-Patella Syndrome

Cystic Fibrosis

20

incomplete penetrance

does the effect show up at all?

21

variable expressivity

how much does it show up? is it mild or severe?

22

epistasis

the effect of alleles of one gene may depend on the alleles of another gene

multiple loci working together to control a trait

ex. mouse fur color

23

exception to complementation

interallelic complementation