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Immunology Final Study > Exam 3 > Flashcards

Exam 3 Flashcards

1
Q

Typical lab results typically seen in lymphoid chronic thyroiditis are:

Decreased TSH, increased T4 and T3, anti-TPO antibodies absent
Increased TSH and T4, decreased T3, anti-TPO antibodies present
Increased TSH, decreased T3 and T4, anti-TPO antibodies present
Increased TSH, decreased T3, and T4, anti-TPO antibodies absent

A

Increased TSH, decreased T3 and T4, anti-TPO antibodies present

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2
Q

This type of ANA pattern characterizes anti-DNA nucleoprotein antibodies

Homogeneous
Speckled
Nucleolar
Centromere

A

Homogeneous

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3
Q

Autoimmune hepatitis is most common in:

Young men
Older men
Young women
Alcoholics

A

Young women

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4
Q

B cells undergo a second process of selection during their maturation.

True
False

A

True

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5
Q

The thyroid is responsible for deleting autoreactive T cells that have the potential to cause autoimmune disease.

True
False

A

False

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6
Q

Tolerance is a lack of immune response to self antigens.

True
False

A

True

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7
Q

Which are the pathways for T cell tolerance

Clonal abortion
Functional deletion
Clonal exhaustion
T cell suppression
Antibody forming cell blockade

A

Clonal abortion
Functional deletion
T cell suppression

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8
Q

What are the pathways of B cell tolerance

Clonal abortion
Clonal exhaustion
Functional deletion
T cell suppression
Antibody forming cell blockade

A

Clonal abortion
Clonal exhaustion
Functional deletion
Antibody forming cell blockade

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9
Q

What stage of autoimmune disease is associated with active disease state.

Initiation
Propagation
Resolution

A

Propagation

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10
Q

Which is not an example of an organ-specific autoimmune disorder.

Rheumatoid arthritis
Type 1 diabetes
Multiple sclerosis
Thyroid disease

A

Rheumatoid arthritis

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11
Q

Antinuclear antibodies include all but:

DNA
Histone
Nonhistone protein antibodies
Antihistamine antibodies

A

Antihistamine antibodies

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12
Q

This is a chronic, multisystem disease that causes thickening of the skin.

Vasculitis
Eosinophilia-myalgia syndrome
Systemic lupus erythematosus
Progressive systemic sclerosis

A

Progressive systemic sclerosis

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13
Q

This disorder is linked to exposure to L-tryptophan.

Eosinophilia-myalgia syndrome
Carditis
Progressive systemic sclerosis
Vasculitis

A

Eosinophilia-myalgia syndrome

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14
Q

The presence of this antibody doesn’t exclude or confirm Hashimotos, can be positive in Graves patients, thyroid cancers, and subacute thyroiditis.

CA2
Thyroid microsome
Thyroglobulin
Thyronine

A

Thyroglobulin

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15
Q

Pernicious anemia is caused by a deficiency of:

Vitamin C
Vitamin B12
Vitamin D
Iron

A

Vitamin B12

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16
Q

Polyclonal gammopathies can be exhibited as a secondary manifestation of all of the following except:

Chronic infection
Chronic liver disease
Multiple myeloma
Rheumatoid connective disease

A

Multiple myeloma

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17
Q

Which cytokine is essential for survival and growth of myeloma cells.

IL-3
IL-6
IL-9
IL-12

A

IL-6

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18
Q

Which of the following is not true of Sjogren syndrome?

Chronic inflammatory disease that affects lacrimal, salivary, and other excretory glands
Secondary form is associated with rheumatoid arthritis
Primary form is not associated with other disorders
Hypogammaglobulinemia

A

Hypogammaglobulinemia

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19
Q

Warm-reactive autoantibodies react at ______temperature.

37oC
30oC
57oC
4oC

A

37oC

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20
Q

This type of ANA pattern is detected against anti-RNP and anti-Sm.

Homogeneous
Speckled
Nucleolar
Centromere

A

Speckled

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21
Q

This is the most common demyelinating disease of the CNS

Amyotrophic Lateral Sclerosis
Multiple Sclerosis
Myasthenia Gravis
Guillain-Barre Syndrome

A

Multiple Sclerosis

22
Q

One of the most frequent causes of drug-induced lupus is:

Chloramphenicol
Procainamide hydrochloride
Isoniazid
Penicillin

A

Procainamide hydrochloride

23
Q

SLE is more common in:

Male infants
Female infants
Adolescent through middle-aged women
Adolescent through middle-aged men

A

Adolescent through middle-aged women

24
Q

Patients with SLE typically manifest:

Butterfly rash over the bridge of the nose
Skin lesions on the arms and legs
Ulcerations on the trunk
Photophobia

A

Butterfly rash over the bridge of the nose

25
Q

Rheumatoid arthritis is known to be caused by genetic issues.

True
False

A

False

26
Q

Arrange the steps of pathogenesis of rheumatoid arthritis is the correct order.

Initiation of synovitis by the primary causative factor
Transition of an inflammatory reaction in the synovium to a proliferative, destructive tissue process
Subsequent immunologic events that perpetuate the initial inflammatory reaction

A

Initiation of synovitis by the primary causative factor
Subsequent immunologic events that perpetuate the initial inflammatory reaction
Transition of an inflammatory reaction in the synovium to a proliferative, destructive tissue process

27
Q

Which is the least common of the major immunoglobulin classes of rheumatoid factor.

IgA
IgG
IgM

A

IgA

28
Q

Development of autoantibodies in SLE is due to defective ______tolerance for self antigens.

T cell
B cell
Dendritic cell
Macrophage

A

B cell

29
Q

Which of the following is not associated with SLE.

Butterfly rash
Psychosis
Inflammation
Hives

A

Hives

30
Q

Bence Jones (BJ) proteins are soluble at room temperature and become insoluble (precipitate) near:

37oC
50oC
60oC
100oC

A

60oC

31
Q

Which cell type(s) is/are involved in the pathogenesis of SLE?

B lymphs
T lymphs
Dendritic cells
All of the above
None of the above

A

All of the above

32
Q

Discoid lupus is always limited to the ______.

Skin
Chest
Kidneys
Kidneys

A

Skin

33
Q

The presence of lupus anticoagulants increases the risk of bleeding.

True
False

A

False

34
Q

________ antibodies are the only autoantibodies that may be used to monitor disease activity of SLE.

Anti-ssDNA
histones
Anti-dsDNA
Anti-nDNA

A

Anti-dsDNA

35
Q

ANAs can be used to confirm SLE.

True
False

A

False

36
Q

This type of ANA pattern is highly selective for CREST variant of systemic sclerosis.

Speckled
Nucleolar
Homogenous
Centromere

A

Centromere

37
Q

Which type of cells are responsible for initiating the immune response to islet cells in Type 1 Diabetes

CD4+ T cells
CD8+ T cells
B cells
Macrophages

A

CD4+ T cells

38
Q

Which test is most specific for rheumatoid arthritis?

anti-CCPs
Rheumatoid Factor
ESR
ANAs

A

anti-CCPs

39
Q

To be diagnosed with Juvenile Idiopathic Arthritis you need to be under the age of _____.

6 years
10 years
16 years
18 years

A

16 years

40
Q

What is the most frequent cause of death in a patient with multiple myeloma?

Skeletal distruction
Chronic renal failure
Neurologic disorders
Infectious diseases

A

Infectious diseases

41
Q

Patients with multiple myeloma have defects in:

Cellular immunity
Humoral immunity
Synthesis of normal immunoglobulins
Both b and c

A

Both b and c

42
Q

Cryoglobulins are proteins that precipitate or gel at:

-18oC
-4oC
0oC
4oC

A

0oC

43
Q

Most patients with multiple myeloma manifest:

Bone pain
Acute renal failure
No symptoms
Hepatomegaly and splenomegaly

A

Bone pain

44
Q

Patients with Waldenstrom macroglobulinemia exhibit abnormally large amounts of:

IgM
IgG
IgE
IgA

A

IgM

45
Q

Monoclonal gammopathy of undetermined significance (MGUS) represents a:

Monoclonal protein in patients with no features of multiple myeloma or related malignant disorders
Disorder that can evolve into a malignant monoclonal gammopathy
Serum monoclonal protein concentration less than 3 g/dL
All of the above

A

All of the above

46
Q

MGUS is characterized by all of the following except:

Less than 10% plasma cells in the bone marrow
Presence of lytic bone lesions
Anemia
Hypercalcemia

A

Presence of lytic bone lesions

47
Q

Light chain disease represents about ________ of monoclonal gammopathies.

5-10%
10-15%
15-25%
25-50%

A

10-15%

48
Q

This figure represents the serum electrophoresis of a patient with:

Waldenstrom macroglobulinemia
Multiple myeloma
No protein abnormality
Polyclonal gammopathy

A

Multiple myeloma

49
Q

Which is the most common immunoglobulin affected with multiple myeloma?

IgG
IgM
IgA
IgD

A

IgG

50
Q

In light chain disease, only _______ and _______ monoclonal light chains, or BJ proteins are produced

kappa, gamma
alpha, beta
kappa, lambda
lambda, gamma

A

kappa, lambda

Immunology Final Study (3 decks)

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