Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Immunology Final Study > Exam 3 > Flashcards

Exam 3 Flashcards

(50 cards)

Start Studying
1
Q

Typical lab results typically seen in lymphoid chronic thyroiditis are:

Decreased TSH, increased T4 and T3, anti-TPO antibodies absent
Increased TSH and T4, decreased T3, anti-TPO antibodies present
Increased TSH, decreased T3 and T4, anti-TPO antibodies present
Increased TSH, decreased T3, and T4, anti-TPO antibodies absent

A

Increased TSH, decreased T3 and T4, anti-TPO antibodies present

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

This type of ANA pattern characterizes anti-DNA nucleoprotein antibodies

Homogeneous
Speckled
Nucleolar
Centromere

A

Homogeneous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Autoimmune hepatitis is most common in:

Young men
Older men
Young women
Alcoholics

A

Young women

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

B cells undergo a second process of selection during their maturation.

True
False

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

The thyroid is responsible for deleting autoreactive T cells that have the potential to cause autoimmune disease.

True
False

A

False

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Tolerance is a lack of immune response to self antigens.

True
False

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which are the pathways for T cell tolerance

Clonal abortion
Functional deletion
Clonal exhaustion
T cell suppression
Antibody forming cell blockade

A

Clonal abortion
Functional deletion
T cell suppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the pathways of B cell tolerance

Clonal abortion
Clonal exhaustion
Functional deletion
T cell suppression
Antibody forming cell blockade

A

Clonal abortion
Clonal exhaustion
Functional deletion
Antibody forming cell blockade

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What stage of autoimmune disease is associated with active disease state.

Initiation
Propagation
Resolution

A

Propagation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which is not an example of an organ-specific autoimmune disorder.

Rheumatoid arthritis
Type 1 diabetes
Multiple sclerosis
Thyroid disease

A

Rheumatoid arthritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Antinuclear antibodies include all but:

DNA
Histone
Nonhistone protein antibodies
Antihistamine antibodies

A

Antihistamine antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

This is a chronic, multisystem disease that causes thickening of the skin.

Vasculitis
Eosinophilia-myalgia syndrome
Systemic lupus erythematosus
Progressive systemic sclerosis

A

Progressive systemic sclerosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

This disorder is linked to exposure to L-tryptophan.

Eosinophilia-myalgia syndrome
Carditis
Progressive systemic sclerosis
Vasculitis

A

Eosinophilia-myalgia syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

The presence of this antibody doesn’t exclude or confirm Hashimotos, can be positive in Graves patients, thyroid cancers, and subacute thyroiditis.

CA2
Thyroid microsome
Thyroglobulin
Thyronine

A

Thyroglobulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Pernicious anemia is caused by a deficiency of:

Vitamin C
Vitamin B12
Vitamin D
Iron

A

Vitamin B12

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Polyclonal gammopathies can be exhibited as a secondary manifestation of all of the following except:

Chronic infection
Chronic liver disease
Multiple myeloma
Rheumatoid connective disease

A

Multiple myeloma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Which cytokine is essential for survival and growth of myeloma cells.

IL-3
IL-6
IL-9
IL-12

A

IL-6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Which of the following is not true of Sjogren syndrome?

Chronic inflammatory disease that affects lacrimal, salivary, and other excretory glands
Secondary form is associated with rheumatoid arthritis
Primary form is not associated with other disorders
Hypogammaglobulinemia

A

Hypogammaglobulinemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Warm-reactive autoantibodies react at ______temperature.

37oC
30oC
57oC
4oC

A

37oC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

This type of ANA pattern is detected against anti-RNP and anti-Sm.

Homogeneous
Speckled
Nucleolar
Centromere

A

Speckled

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

This is the most common demyelinating disease of the CNS

Amyotrophic Lateral Sclerosis
Multiple Sclerosis
Myasthenia Gravis
Guillain-Barre Syndrome

Study These Flashcards
A

Multiple Sclerosis

22
Q

One of the most frequent causes of drug-induced lupus is:

Chloramphenicol
Procainamide hydrochloride
Isoniazid
Penicillin

Study These Flashcards
A

Procainamide hydrochloride

23
Q

SLE is more common in:

Male infants
Female infants
Adolescent through middle-aged women
Adolescent through middle-aged men

Study These Flashcards
A

Adolescent through middle-aged women

24
Q

Patients with SLE typically manifest:

Butterfly rash over the bridge of the nose
Skin lesions on the arms and legs
Ulcerations on the trunk
Photophobia

Study These Flashcards
A

Butterfly rash over the bridge of the nose

25
Rheumatoid arthritis is known to be caused by genetic issues. True False
False
26
Arrange the steps of pathogenesis of rheumatoid arthritis is the correct order. Initiation of synovitis by the primary causative factor Transition of an inflammatory reaction in the synovium to a proliferative, destructive tissue process Subsequent immunologic events that perpetuate the initial inflammatory reaction
Initiation of synovitis by the primary causative factor Subsequent immunologic events that perpetuate the initial inflammatory reaction Transition of an inflammatory reaction in the synovium to a proliferative, destructive tissue process
27
Which is the least common of the major immunoglobulin classes of rheumatoid factor. IgA IgG IgM
IgA
28
Development of autoantibodies in SLE is due to defective ______tolerance for self antigens. T cell B cell Dendritic cell Macrophage
B cell
29
Which of the following is not associated with SLE. Butterfly rash Psychosis Inflammation Hives
Hives
30
Bence Jones (BJ) proteins are soluble at room temperature and become insoluble (precipitate) near: 37oC 50oC 60oC 100oC
60oC
31
Which cell type(s) is/are involved in the pathogenesis of SLE? B lymphs T lymphs Dendritic cells All of the above None of the above
All of the above
32
Discoid lupus is always limited to the ______. Skin Chest Kidneys Kidneys
Skin
33
The presence of lupus anticoagulants increases the risk of bleeding. True False
False
34
________ antibodies are the only autoantibodies that may be used to monitor disease activity of SLE. Anti-ssDNA histones Anti-dsDNA Anti-nDNA
Anti-dsDNA
35
ANAs can be used to confirm SLE. True False
False
36
This type of ANA pattern is highly selective for CREST variant of systemic sclerosis. Speckled Nucleolar Homogenous Centromere
Centromere
37
Which type of cells are responsible for initiating the immune response to islet cells in Type 1 Diabetes CD4+ T cells CD8+ T cells B cells Macrophages
CD4+ T cells
38
Which test is most specific for rheumatoid arthritis? anti-CCPs Rheumatoid Factor ESR ANAs
anti-CCPs
39
To be diagnosed with Juvenile Idiopathic Arthritis you need to be under the age of _____. 6 years 10 years 16 years 18 years
16 years
40
What is the most frequent cause of death in a patient with multiple myeloma? Skeletal distruction Chronic renal failure Neurologic disorders Infectious diseases
Infectious diseases
41
Patients with multiple myeloma have defects in: Cellular immunity Humoral immunity Synthesis of normal immunoglobulins Both b and c
Both b and c
42
Cryoglobulins are proteins that precipitate or gel at: -18oC -4oC 0oC 4oC
0oC
43
Most patients with multiple myeloma manifest: Bone pain Acute renal failure No symptoms Hepatomegaly and splenomegaly
Bone pain
44
Patients with Waldenstrom macroglobulinemia exhibit abnormally large amounts of: IgM IgG IgE IgA
IgM
45
Monoclonal gammopathy of undetermined significance (MGUS) represents a: Monoclonal protein in patients with no features of multiple myeloma or related malignant disorders Disorder that can evolve into a malignant monoclonal gammopathy Serum monoclonal protein concentration less than 3 g/dL All of the above
All of the above
46
MGUS is characterized by all of the following except: Less than 10% plasma cells in the bone marrow Presence of lytic bone lesions Anemia Hypercalcemia
Presence of lytic bone lesions
47
Light chain disease represents about ________ of monoclonal gammopathies. 5-10% 10-15% 15-25% 25-50%
10-15%
48
This figure represents the serum electrophoresis of a patient with: Waldenstrom macroglobulinemia Multiple myeloma No protein abnormality Polyclonal gammopathy
Multiple myeloma
49
Which is the most common immunoglobulin affected with multiple myeloma? IgG IgM IgA IgD
IgG
50
In light chain disease, only _______ and _______ monoclonal light chains, or BJ proteins are produced kappa, gamma alpha, beta kappa, lambda lambda, gamma
kappa, lambda

Immunology Final Study (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions