Exam 3 lecture 15 study of FGGY by waddell

Question 1

What is the independent and dependent variable of this study

Answer 1

I=ectopic expression of FGGY isoforms in muscle cells

D=markers of muscle cell differentiation , and activity levels of MAP kinase and Akt signaling pathways

Question 2

List a few test they conducted

Answer 2

microarray analysis
bioinformatic analysis
cloning and identification
quatitative PCR

Question 3

what was the main conclusions of the study?

Answer 3

FGGY is expressed in skeletal muscle and upregulated in response to denervation induced atrophy

suggests FGGY plays a signifcant role in molecular mechanisms of muscle atrophy.

Question 4

FGGY can serve as a potential what/

Answer 4

therapeutic target for muscle-wasting conditions

Question 5

FGGY plays a role in muscle atrophy by influencing what

Answer 5

Gene expression and key signaling pathways that regulate muscle cell function.

Question 6

expression levels of FGGY does what

Answer 6

FGGY is upregulated in skeletal muscle in response to denervation.
suggests FGGY is linked to muscle wasting conditions

Question 7

FGGY impact on cell signaling pathways suggest

Answer 7

overexpression of specific FGGY Isoform shows to inhibit map kinase and akt signaling which are essential for muscle growth

Question 8

influence on muscle atrophy

Answer 8

increases FGGY expressions contributes to muscle atrophy and suppress the cellular mechanism that maintain muscle mass.

Question 9

Fggy interfers with AKT pathway by what

Answer 9

preventing phosphorylation of akt

Question 10

fggy interfers with map kinase pathway by what

Answer 10

preventing phosphorlyation of erk

Question 11

fggy destabilizes what?

Answer 11

Akt