Exam 3 (Week 12)

Question 1

What is the brand name of cimetidine?

Answer 1

tagamet

Question 2

Pharmacological class of cimetidine:

Answer 2

Histamine2 (H2) receptor antagonist

Question 3

Therapeutic class of cimetidine:

Answer 3

Antiulcer/Drug for Peptic Ulcer Disease (PUD)

Question 4

MOA of cimetidine:

Answer 4

blocking H2 receptors on the parietal cells in the stomach.

2. reduces both the volume of gastric juice and its hydrogen ion concentration.

Question 5

Uses of cimetidine:

Answer 5

1. treatment of gastric and duodenal ulcers
2. GERD
3. zollinger ellison syndrome
   Available over the counter for:
   heartburn, acid indigestion, and sour stomach

Question 6

ADE of cimetidine:

Answer 6

1. anti-adrenergic effects
2. CNS effects especially in older adults who have renal or hepatic impairment
3. pneumonia

Question 7

1 nursing implication of cimetidine:

Answer 7

to promote smoking cessation

Question 8

What is the brand name of omeprazole?

Answer 8

Prilosec

Question 9

Pharmacological class of omeprazole:

Answer 9

proton pump inhibitor (PPI)/prodrug

Question 10

Therapeutic class of omeprazole:

Answer 10

Antiulcer/Drug for PUD

Question 11

MOA of omeprazole:

Answer 11

prodrug

2. undergoes conversion into its active form within parietal cells in the stomach.
3. active form causes irreversible inhibition of hydrogen-potassium-ATPase (enzyme that generates gastric acid)

Question 12

short term uses of omeprazole:

Answer 12

Short term therapy of…

1. duodenal ulcers
2. gastric ulcers
3. erosive esophagitis
4. GERD

Question 13

long term uses of omeprazole:

Answer 13

hypersecretory conditions (zollinger ellison’s syndrome)

Question 14

ADE of short term use of omeprazole:

Answer 14

minor

Question 15

ADE of long-term use of omeprazole:

Answer 15

1. pneumonia
2. fractures
3. re-bound acid hypersectretion
4. hypomagnesemia
5. infection with C. diff
6. gastric cancer

Question 16

1 nursing implication of omeprazole:

Answer 16

informing the patient about signs and symptoms of respiratory infection

Question 17

What is the brand name of methylcellulose?

Answer 17

Citrucel

Question 18

Pharmacological class of methylcellulose:

Answer 18

Bulk-forming laxative

Question 19

Therapeutic class of methylcellulose:

Answer 19

Constipation

Question 20

What does methylcellulose have the same effect as?

Answer 20

The same impact on bowel function as dietary fiber (non-digestible and non-absorbable)

Question 21

MOA of methylcellulose:

Answer 21

The drug swells in water to form a viscous solution softening fecal mass and increasing its bulk.

Question 22

Uses of methylcellulose:

Answer 22

Temporary treatment of constipation

2. Direticulosis
3. irritable bowel syndrome

Question 23

ADE of methylcellulose:

Answer 23

1. esophageal obstruction if the drugs are swallowed in the absence of fluids
2. intestinal obstruction or impaction (passage through the intestine is impeded)

Question 24

1 nursing implication of methylcellulose:

Answer 24

instruct the patient to take the med with full glass of water or juice

Question 25

What is the brand name of bisacodyl?

Answer 25

Dulcolax

Question 26

Pharmacological class of bisacodyl:

Answer 26

stimulant laxative

Question 27

Therapeutic class of bisacodyl:

Answer 27

constipation

Question 28

What is important to note about stimulant laxatives?

Answer 28

widely used and abused

Question 29

How many effects do stimulant laxatives have on the bowel?

Answer 29

2

Question 30

What is the brand name of magnesium hydroxide?

Answer 30

milk of magnesia

Question 31

Pharmacological class of magnesium hydroxide:

Answer 31

osmotic laxative

Question 32

Therapeutic class of magnesium hydroxide:

Answer 32

constipation

Question 33

What is magnesium hydroxide considered?

Answer 33

a laxative salt

Question 34

What is the brand name of ondansetron?

Answer 34

Zofran

Question 35

Pharmacological class of ondansetron:

Answer 35

serotonin receptor antagonist

Question 36

Therapeutic class of ondansetron:

Answer 36

antiemetic

Question 37

MOA of ondansetron:

Answer 37

blocking type 3 serotonin receptors located in the CTZ and on afferent fagal neurons in the upper GI tract.

Question 38

When is ondansetron more effective?

Answer 38

when it is combined with a glucocorticoid

Question 39

Uses of ondansetron:

Answer 39

management of chemotherapy induced nausea and vomiting | nausea and vomiting associated with anesthesia, biro gastritis, and morning sickness of pregnancy

Question 40

ADE of ondansetron:

Answer 40

1. headache 2. diarrhea 3. dizziness 4. Prolongnation of QT interval

Question 41

1 nursing implication of ondansetron:

Answer 41

monitoring electrolytes

Question 42

What is the brand name of metoclopramide?

Answer 42

Reglan

Question 43

Pharmacological class of metoclopramide:

Answer 43

Dopamine and serotonin antagonist in chemoreceptor trigger zone (CTZ)/enhances actions of acetylcholine

Question 44

Therapeutic class of metoclopramide:

Answer 44

Antiemetic/Prokinetic

Question 45

MOA of metoclopramide:

Answer 45

1. suppresses emesis by blocking receptors for dopamine and serotonin in the CTZ 2. Increases upper GI motility by enhancing the actions of acetylcholine

Question 46

How can metoclopramide be given?

Answer 46

orally or intravenously

Question 47

Uses of oral metoclopramide:

Answer 47

1. diabetic gastroporesis | 2. suppression of GERD

Question 48

Uses of intravenous metoclopramide:

Answer 48

1. suppress post-operative nausea and vomiting 2. suppress chemotherapy induced nausea and vomiting 3. facilitation of certain GI procedures

Question 49

AE of metoclopramide depend on what?

Answer 49

dose

Question 50

AE high dose therapy of metoclopramide:

Answer 50

1. sedation | 2. diarrhea

Question 51

AE of long-term high dose therapy of metoclopramide:

Answer 51

irreversible tardive dyskinesia

Question 52

1 nursing implication of metoclopramide:

Answer 52

educate patient regarding sedative effects

Question 53

What is the brand name of sulfasalazine?

Answer 53

Azulfidine

Question 54

Pharmacological class of sulfasalazine:

Answer 54

5-aminosalicylate (5-ASA)

Question 55

Therapeutic class of sulfasalazine:

Answer 55

Drug for inflammatory bowel disease (IBD)

Question 56

MOA of sulfasalazine:

Answer 56

broken down into 5-ASA and sulfa pyrodine 1. 5-ASA acts by suppressing prostaglandin synthesis and suppressing the migration of inflammatory cells into the infected area. 2. sulfa pyrodine acts by caused adverse effects.

Question 57

Uses of sulfasalazine:

Answer 57

1. manage acute episodes of mild to moderate ulcerative colitis 2. crohn's disease

Question 58

ADE of sulfasalazine:

Answer 58

1. nausea 2. fever 3. rash 4. arthralgia 5. hematologic disorders

Question 59

1 nursing implication of sulfasalazine:

Answer 59

monitor complete blood cell counts

Question 60

What is the brand name of ursodial?

Answer 60

actigall

Question 61

Pharmacological class of ursodial:

Answer 61

Ursodeoxycholic acid/analog of chenodiol

Question 62

Therapeutic class of ursodial:

Answer 62

Drug used to dissolve gallstones