Exam 4 Flashcards

(42 cards)

1
Q

Long-term potentiation (LTP) is best defined as:

A

A long-lasting increase in synaptic strength following high-frequency stimulation.

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2
Q

Which stage of memory involves the temporary storage of information for only a few seconds in the absence of rehearsal?

A

Short-term memory (STM)

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3
Q

Damage to the cerebellum leads to severe impairments in forming new declarative memories.

A

False

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4
Q

Priming is best described as:

A

A change in processing a stimulus following previous exposure.

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5
Q

Cerebellum
Amygdala
Dorsomedial Thalamus
Mammillary Bodies
Hippocampus

A
  • Critical for the timing and coordination of conditioned motor responses (e.g., the eye-blink reflex).
  • Modulates memory strength through emotional arousal and fear conditioning.
  • Part of the medial diencephalon that relays memory-related information and is often damaged in amnesic conditions.
  • Works as a relay in the memory circuit; its damage contributes to severe memory deficits.
  • Essential for forming and consolidating new declarative memories.
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6
Q

Semantic Memory
Procedural Memory
Nondeclarative Memory
Declarative Memory
Episodic Memory

A
  • General knowledge about facts and concepts.
  • Memory expressed through the performance of skills.
  • Memory demonstrated through behavior without conscious recollection.
  • Memory that can be consciously recalled and described.
  • Memory for personal events and experiences.
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7
Q

Patient H.M. could improve on mirror tracing tasks even though he was unable to form new declarative memories.

A

True

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8
Q

Which type of amnesia is defined as the difficulty in forming new memories after the onset of a disorder?

A

Anterograde amnesia

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9
Q

Select all the brain regions that have been implicated in forming new declarative memories:

A
  • Dorsomedial thalamus
  • Entorhinal cortex
  • Perirhinal cortex
  • Mammillary bodies
  • Parahippocampal cortex
  • Hippocampus
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10
Q

Which brain structure is most critical for forming new declarative memories?

A

Hippocampus

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11
Q

What is memory?

A

The process of acquiring, storing, and retrieving information.

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12
Q

Which receptor is key for the induction of long-term potentiation (LTP) in the hippocampus?

A

NMDA recpetor

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13
Q

Patient H.M. is best known for which memory impairment?

A

Inability to form new declarative memories

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14
Q

Which brain region is primarily involved in the classical conditioning of the eye-blink reflex?

A

Cerebellum

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15
Q

Which type of memory is demonstrated by skills such as mirror tracing or riding a bike?

A

Nondeclarative (procedural) memory

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16
Q

Which behavior exemplifies behavioral compensation for thermoregulation?

A

Moving toward a heat source when feeling cold.

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17
Q

Select all hormones that are involved in short-term gut regulation of appetite.

A
  • GLP-1
  • PYY3-36
  • Cholecystokinin (CCK)
  • Ghrelin
18
Q

In homeostatic systems, what is a “set zone”?

A

A range around the set point within which the regulated variable is maintained.

19
Q

Glucagon
Glycogen
Insulin
Basal metabolism

A
  • A hormone that increases blood glucose levels by promoting glycogen breakdown.
  • A stored form of glucose found primarily in the liver and muscles.
  • A hormone that facilitates glucose uptake into cells and promotes energy storage.
  • The minimal amount of energy expended to maintain essential physiological functions at rest.
20
Q

How is osmosis best defined?

A

The passive movement of water across a semipermeable membrane to equalize solute concentrations.

21
Q

What is homeostasis?

A

Maintenance of a relatively constant internal environment through regulatory processes.

22
Q

In response to a high-salt diet, the extracellular fluid becomes hypertonic, which triggers osmotic thirst.

23
Q

Osmotic thirst is initiated when:

A

The extracellular fluid becomes too concentrated with solutes, drawing water out of cells.

24
Q

What role does insulin play in energy homeostasis?

A

It facilitates glucose uptake into cells and promotes the conversion of excess glucose into glycogen.

25
What characterizes a semipermeable membrane?
It allows certain molecules (like water) to pass while restricting others (such as many solutes).
26
Which hormone, released by the posterior pituitary, promotes water reabsorption in the kidneys?
Vasopressin (also known as ADH).
27
The hypothalamus is solely responsible for regulating appetite, with no input from other brain regions or peripheral signals.
False
28
Which hormone is produced by adipose tissue to signal long-term energy reserves?
Leptin
29
Which statement best distinguishes endotherms from ectotherms?
Endotherms generate their own heat through metabolic processes, whereas ectotherms rely on external heat sources.
30
Bariatric surgery aims only to remove excess fat tissue and does not affect hormonal signals related to appetite.
False
31
Which concept describes how a system counteracts deviations from a desired value by triggering corrective actions?
Negative feedback
32
Which receptor type plays a key role in detecting low blood volume (hypovolemia) to trigger thirst?
Baroreceptors
33
Which type of plaque is described as non-fibrillar, often an early or precursor lesion in Alzheimer’s disease?
Diffuse plaque
34
Which APOE gene allele is most strongly linked to an increased risk of late-onset Alzheimer’s disease?
APOE-e4
35
Abnormal phosphorylation of which protein leads to the formation of neurofibrillary tangles in Alzheimer’s disease?
Tau protein
36
Which secretase cleaves within the beta-amyloid region of the amyloid precursor protein, thereby preventing the formation of beta-amyloid?
Alpha-secretase
37
Which two hallmark lesions are found in Alzheimer’s disease?
Amyloid plaques and neurofibrillary tangles
38
Who is credited with first describing the neuropathological features characteristic of Alzheimer’s disease in 1906?
Alois Alzheimer
39
Regarding familial Alzheimer’s disease, which statement is true?
It is linked to mutations in genes such as APP, presenilin 1, and presenilin 2 and usually presents early.
40
Which factor contributes to the underdiagnosis of Alzheimer’s dementia?
Early symptoms are mild and often mistaken for normal aging.
41
Which enzyme is responsible for the initial cleavage of amyloid precursor protein in the pathway that produces beta-amyloid?
β-secretase (BACE-1)
42
How does Alzheimer’s disease typically progress in terms of cognitive decline?
It starts with mild memory and language issues that gradually worsen and interfere with daily activities.