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Flashcards in Exam I Deck (88)
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1

physical barrier of skin is approx

2 (sq meters)

2

physical barrier of mucous membranes is apprx

400 (sq meters)

3

- prevents attachment of organisms
- contains many *glycoproteins*
- aids in clearing infections

mucus

4

components of innate immune system

monocytes
macrophases
neutrophils
dendritic cells

5

cells that kill and have antigen presentation

monocytes/macrophages

6

cells that are professional killers

neurtrophils

7

cells that are killers

natural killer cells

8

cells that antigen capture in one location and presentation in another

dendritic cells

9

# of proteins that are produced by what organ in the *complement system*

20 proteins in liver

10

cells included in *adaptive* immune system

B cells
T cells

11

antibodies that don't kill, but mark a target for destruction (OPSONIZE)
-use modular design

B cells

12

different types of T cells

T helper cells
T kiler cells
Regulatory T cells

13

type of design that B cells use to mix and match, cut and paste different DNA variations

modular design

14

What is required for T cell activation?

antigen presentation

15

cell types that present antigen to T cells

dendritic cells
macrophages
B cells

16

hormone like messengers (proteins) produced by certain immune cells, especially T helper cells, that communicate with other cells and affect immune response

cytokines

17

IL-1, IL-2, INFgamma, TNF are all examples of

cytokines

18

MHC proteins that are found on virtually ALL cells of the body; scanned by killer T cells

Class I MHC

19

MHC proteins that are typically found only on APC; displays what has been killed at battle site (external)

Class II MHC

20

50-70% of circulating WBC's from myeloid lineage are

neutrophils

21

2 types of lineage in immune system

myeloid
lymphoid

22

20-40% of circulating WBC's are from:

lymphoid lineage

23

functions of complement system:

opsonization (mark bad guys)
act as chemical signals to attract phagocytes
make MACs (membrane attack complexes)

24

system that requires *activation* through alternate, lectin or classical pathways

complement system

25

two pathways for complement protein activation that are NOT dependent on antibodies

alternate
lectin

26

only pathway for complement protein activation that IS dependent on antibodies

classical

27

pathway in which certain complement proteins "spontaneously" activate and attach to surfaces

alternate

28

C3 spilts in two parts in alternate pathway

C3a C3b

29

any surface not protected against binding by complement fragments will be targets for destruction in which pathway? (default option)

alternate

30

molecule that will either get *neutralized* by water within 60 microseconds OR bind to *BACTERIA surface --> AMINO or HYDROXYL groups*

C3b (alternate pathway)