Flashcards in Exam I Deck (88)
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1
physical barrier of skin is approx
2 (sq meters)
2
physical barrier of mucous membranes is apprx
400 (sq meters)
3
- prevents attachment of organisms
- contains many *glycoproteins*
- aids in clearing infections
mucus
4
components of innate immune system
monocytes
macrophases
neutrophils
dendritic cells
5
cells that kill and have antigen presentation
monocytes/macrophages
6
cells that are professional killers
neurtrophils
7
cells that are killers
natural killer cells
8
cells that antigen capture in one location and presentation in another
dendritic cells
9
# of proteins that are produced by what organ in the *complement system*
20 proteins in liver
10
cells included in *adaptive* immune system
B cells
T cells
11
antibodies that don't kill, but mark a target for destruction (OPSONIZE)
-use modular design
B cells
12
different types of T cells
T helper cells
T kiler cells
Regulatory T cells
13
type of design that B cells use to mix and match, cut and paste different DNA variations
modular design
14
What is required for T cell activation?
antigen presentation
15
cell types that present antigen to T cells
dendritic cells
macrophages
B cells
16
hormone like messengers (proteins) produced by certain immune cells, especially T helper cells, that communicate with other cells and affect immune response
cytokines
17
IL-1, IL-2, INFgamma, TNF are all examples of
cytokines
18
MHC proteins that are found on virtually ALL cells of the body; scanned by killer T cells
Class I MHC
19
MHC proteins that are typically found only on APC; displays what has been killed at battle site (external)
Class II MHC
20
50-70% of circulating WBC's from myeloid lineage are
neutrophils
21
2 types of lineage in immune system
myeloid
lymphoid
22
20-40% of circulating WBC's are from:
lymphoid lineage
23
functions of complement system:
opsonization (mark bad guys)
act as chemical signals to attract phagocytes
make MACs (membrane attack complexes)
24
system that requires *activation* through alternate, lectin or classical pathways
complement system
25
two pathways for complement protein activation that are NOT dependent on antibodies
alternate
lectin
26
only pathway for complement protein activation that IS dependent on antibodies
classical
27
pathway in which certain complement proteins "spontaneously" activate and attach to surfaces
alternate
28
C3 spilts in two parts in alternate pathway
C3a C3b
29
any surface not protected against binding by complement fragments will be targets for destruction in which pathway? (default option)
alternate
30
