Flashcards in Key Concepts- Exam I Deck (108)
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1
physical barrier with greatest surface area
mucous membrane (400 sq meters)
2
physical barrier with least surface area
skin (2 sq meters)
3
parts of innate immune system
complement proteins
neutrophils
macrophages/moncytes
4
parts of adaptive immune system
B cells
T cells
5
type of cell that is important bridge between innate and adaptive immune systems
dendritic cells
6
complement protein activation that is dependent on antibodies
classical pathway
7
complement protein activation that is independent of antibodies
alternate pathway
MBL pathway (lectin)
8
functions of complement system
opsonize
kill
chemoattrants
building MACs
9
state that macrophages are good antigen presenter
primed
10
state that macrophages are garbage collectors
resting
11
state that macrophage receives direct signal from invader
hyperactive
12
function of ICAM on surface of endothelial cells
binds INTEGRIN on surface of neutrophil to stop neutrophil from rolling
13
ICAM is expressed on surface of
endothelial cell
14
SLIG is expressed on surface of
neutrophil
15
when endothelial cells alarmed, they EXPRESS
SLIG (not very strong signal)
16
Neutrophil brings _____ to surface
integrin
17
once neutrophil is stopped, what prys apart endothelial cells
chemoattractants (C5a)
18
two inflammatory signals that a neutrophil recognizes
LPS
C5a
19
When INT appears on neutrophil surface, it interacts with
ICAM (very strong)
20
cytokine that activates neutrophils
TNF
21
cytokine that activates/primes macrophages
IFN-y
22
*hyperactive* macrophages secrete 2 things:
TNF
IL-12
23
organ that is primary source of complement proteins
liver
24
major role of TNF
mediates inflammation
25
molecule that is native to bacteria cell wall that can bind and stimulate BOTH NK cells and macrophages
LPS
26
receptors that bind to MHC I receptors displaying peptide fragment elicit what response:
don't kill
27
receptors that bind to activating receptors (PAMPs) displaying peptide fragment elicit what response:
kill
28
NK cells produce:
IFN-y
IL-2
29
molecules that can activate NK cells
LPS
IFN-alpha
IFN-beta
30
