Key Concepts- Exam I Flashcards Preview

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Flashcards in Key Concepts- Exam I Deck (108)
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1

physical barrier with greatest surface area

mucous membrane (400 sq meters)

2

physical barrier with least surface area

skin (2 sq meters)

3

parts of innate immune system

complement proteins
neutrophils
macrophages/moncytes

4

parts of adaptive immune system

B cells
T cells

5

type of cell that is important bridge between innate and adaptive immune systems

dendritic cells

6

complement protein activation that is dependent on antibodies

classical pathway

7

complement protein activation that is independent of antibodies

alternate pathway
MBL pathway (lectin)

8

functions of complement system

opsonize
kill
chemoattrants
building MACs

9

state that macrophages are good antigen presenter

primed

10

state that macrophages are garbage collectors

resting

11

state that macrophage receives direct signal from invader

hyperactive

12

function of ICAM on surface of endothelial cells

binds INTEGRIN on surface of neutrophil to stop neutrophil from rolling

13

ICAM is expressed on surface of

endothelial cell

14

SLIG is expressed on surface of

neutrophil

15

when endothelial cells alarmed, they EXPRESS

SLIG (not very strong signal)

16

Neutrophil brings _____ to surface

integrin

17

once neutrophil is stopped, what prys apart endothelial cells

chemoattractants (C5a)

18

two inflammatory signals that a neutrophil recognizes

LPS
C5a

19

When INT appears on neutrophil surface, it interacts with

ICAM (very strong)

20

cytokine that activates neutrophils

TNF

21

cytokine that activates/primes macrophages

IFN-y

22

*hyperactive* macrophages secrete 2 things:

TNF
IL-12

23

organ that is primary source of complement proteins

liver

24

major role of TNF

mediates inflammation

25

molecule that is native to bacteria cell wall that can bind and stimulate BOTH NK cells and macrophages

LPS

26

receptors that bind to MHC I receptors displaying peptide fragment elicit what response:

don't kill

27

receptors that bind to activating receptors (PAMPs) displaying peptide fragment elicit what response:

kill

28

NK cells produce:

IFN-y
IL-2

29

molecules that can activate NK cells

LPS
IFN-alpha
IFN-beta

30

cells that kill by poking holes in cell of membrane of invader

complement