Exam II Flashcards

(152 cards)

1
Q

Substance

A

Any natural or synthesized version of product that changes perception, thoughts, etc.

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2
Q

Substance intoxication

A

Experience of significant maladaptive behavioral and psychological symptoms

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3
Q

Substance withdrawal

A

Experience of physiological and behavioral symptoms due to the cessation or reduction of substance use

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4
Q

Withdrawal symptom tendencies

A

Often opposite of substance intoxication

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5
Q

Substance abuse

A

Maladaptive pattern, leading to >= 1 in 12 months, causing impairment of distress

[DRINK]

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6
Q

[DRINK]

A

Substance abuse

D: Dangerous use of substance (e.g. repeatedly driving after drinking)
RI: Role impairment (repeatedly missing class, work, etc.)
N: No respect for the law (multiple DUIs)
K: Keeps drinking in spite of social/interpersonal problems

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7
Q

Substance dependance

A

Maladaptive pattern leading to >= 3 of “TWO-6-PACK”

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8
Q

TWO-6-PACK

A

> = 3 = Substance dependance

T: Tolerance
W: Withdrawal (or use to avoid withdrawal)
O: Occupational, social or recreational activities given up or cut back
6: Nothing - placeholder :)
P: Persistent desire for drug or unable to cut back/control
A: Amount taken larger (in quantity or amount of time) than intended (i.e. excessive)
C: Continued use despite physical and psychological problems from the drug
K: Keep using - great deal of time spent acquiring, using or recovering from use

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9
Q

How does a person become dependent?

A

Brain’s pleasure pathway

Ventral Tegmental Area (VTA) > Nucleus Accumbens > Frontal Cortex

Track lined w/ dopamine receptors (affects movement, cognition, emotion, motivation, & feelings of pleasure)

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10
Q

Biological Theories of SUDs

A
  • 50% of risk of alcohol dependence = genetic
  • Not just 1 gene
  • Not just genes

-Reward sensitivity

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11
Q

Reward sensitivity

A
  • High sensitivity = greater risk for SUD

- Physiological markers make intoxication more or less enjoyable

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12
Q

Psychological Theories of SUDs

A
  • Social learning theory
  • Cognitive theory
  • Personality theory
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13
Q

Social learning theory of SUDs

A
  • Modeling of using/abusing behaviors
  • Follow example of parents
  • Using is acceptable
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14
Q

Cognitive theory of SUDs

A
  • Positive expectations about using
  • Lack of coping skills
  • Use when upset
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15
Q

Personality theory of SUDs

A
  • Impulsivity
  • Sensation-seeking
  • Anti-socal behavior
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16
Q

Sociocultural perspectives of SUDs

A
  • cultural norms
  • gender differences
  • trauma
  • economic factors
  • peer influences
  • family factors
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17
Q

Influence of SUDs in popular media

A
  • 7/10 characters smoke

- 1/3 use drugs and alcohol

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18
Q

Treatments for SUDs

A
  • Behavioral
  • Cognitive
  • Biological
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19
Q

Behavioral treatment for SUDs

A
  • Avoidance of the stimulus
  • Skills training
  • Aversive conditioning
  • Contingency management
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20
Q

Cognitive treatment for SUDs

A

Address faulty expectations or beliefs

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21
Q

Biological treatments for SUDs

A
  • Anxiolytics, antidepressants & antagonists

- Methadone maintenance programs

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22
Q

Efficacy of SUD treatment

A

Available treatments are effective in helping ~ 1/3 of substance abusers remain abstinent for up to a year

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23
Q

What are the models/definitions of addiction not from neuroscience?

A
  • Disease model = medication
  • Choice model = learn to make better decisions
  • Genetic disorder
  • Self-medication

Marc Lewis: “Addiction = accelerated learning” & “Drive=craving”

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24
Q

Nature of the feedback loop in SUDs

A

Craving (drive) Synaptic growth (drug imagery)

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25
Marc Lewis' recommendations for addicts
1. Try to nip it in the bud ASAP - do not focus on drug related cues (avoid them) 2. Minimize ego fatigue - get involved in something else 3. Do not be fooled by addicts ability to minimize/avoid situation
26
Schizophrenia
Severe form of psychosis - inability to tell the difference between the real and unreal
27
Positive symptoms of Schizophrenia
(seen in Schizo, but not others) - Delusions - Hallucinations - Disorganized thought and speech - Disorganized or catatonic behavior
28
Delusion
Belief not rooted in reality - Persecutory = CIA out to get me - Grandiose = I am greater, stronger, have info no one else does - Thought insertion = my thoughts are being controlled by someone else - Thought broadcasting = other people can read my thoughts
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Hallucination
Unreal perceptual experience - Most common: auditory, visual - Also: tactile, somatic & olfactory
30
Disorganized thoughts and speech
- Loose - Tangential - Word salad - Neologisms
31
Tactile hallucination
Connected with sense of touch
32
Somatic hallucination
Things growing inside of you
33
Loose thoughts and speech
Topic to topic
34
Tangential thoughts and speech
Where did that come from?!
35
Word salad thoughts and speech
No sense - all mixed up
36
Neologisms
Adding words together | -Spanglish-esque (Chinish - lol)
37
Disorganized or catatonic behavior
- Catatonia | - Unpredictable or untriggered agitation
38
Catatonia
involves waxy flexibility
39
Negative symptoms of Schizophrenia
Deficit wrt "normal" people - Affective flattening (or blunted effect) - Alogia - Avolition
40
Affective flattening
Blunted effect -Severe reduction or complete absence of affective (emotional) responses to the environment
41
Alogia
Poverty of speech -Severe reduction or complete absence of speech
42
Avolition
Inability to persist @ common, goal-oriented tasks at work, school or home
43
Schizophrenia subtypes
- Paranoid - Disorganized - Catatonic - Undifferentiated - Residual
44
Paranoid symptom of Schizophrenia
Characterized by persecutory & grandiose delusions & hallucinations
45
Disorganized symptom of Schizophrenia
Incoherent speech, inappropriate behavior, flat/inappropriate affect
46
Catatonic
Unresponsiveness to the environment; motor abnormalitites (e.g. "the guard), echolalia or echopraxia
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Echolalia
Person repeats what is heard
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Echopraxia
Imitate what a person does
49
Undifferentiated (Schizo symptom)
Mixutre of: - Paranoia - Disorganized - Catatonic
50
Residual symptom of Schizophrenia
History of at least one acute episode of (+) symptoms, but doesn't show (+) symptoms currently
51
Prognosis of Schizophrenia
- 50-80% re-hospitalization rate - Stabilize w/i 5-10 yrs of 1st episode - Gender & age factors - Sociocultural factors
52
Prognosis of Schizophrenia - Gender and age factors
- Women develop disorder later, w/ milder symptoms & have a more favorable course than men - Functioning improves w/ age
53
Prognosis of Schizophrenia - Sociocultural factors
- Possibly less severe in developing countries - Acceptance of deviant behavior - Gender differences - Social response & treatment availability
54
Psychotic disorders
- Schizophrenia - Brief psychotic disorder - Schizophreniform - Schizoaffective - Delusional disorder - Shared psychotic disorder
55
Brief psychotic disorder
Sudden onset of delusions, hallucinations, disorganized speech &/or behaviors lasting 1-30 days
56
Schizophreniform
Active Schizophrenic symptoms lasting 1-6 months
57
Schizoaffective
Schizophrenic symptoms + major depression or bipolar disorder
58
Delusional disorder
Nonbizarre delusions lasting more than 1 mo; no other significant impairment
59
Shared psychotic disorder
Delusion develops from a relationship w/ another person who has the delusion (AKA 'folie 'a deux'
60
Types of treatment for Schizophrenia
- Biological - Psychological - Social
61
Biological treatment for Schizophrenia
- ECT (not) - Antipsychotic medications - Atypical antipsychotic medications
62
Psychological and social treatment for Schizophrenia
- Behavioral - Cognitive - Social interventions - Family therapy - Assertive Community Treatment Programs
63
Behavioral therapy for treatment of Schizophrenia
- Operant conditioning - modeling - token economies
64
Cognitive therapy for treatment of Schizophrenia
- Recognize and challenge delusions & hallucinations | * View them as symptoms (not reality)
65
Social interventions for treatment of Schizophrenia
- Increase effective social support - Support groups - Learn problem-solving skills, etc.
66
Family therapy for treatment of Schizophrenia
Provide psycho-education plus help families learn to be more supportive w/ lower expressed emotion
67
Assertive Community Treatment Programs for treatment of Schizophrenia
- Provide comprehensive monitoring, support & treatment - Help decrease hospitalization - 70% hospitalization
68
6 Subtypes of major depression
1. Melancholic features 2. Psychotic features 3. Catatonic features 4. Atypical features 5. Postpartum onset 6. Seasonal pattern
69
Lifetime prevalence of major depression
- 16% (varies internationally) - Women>Men - Prevalence decreases from 30-85 yrs.
70
Why does prevalence of major depression decrease after 30-85 yrs?
1. Coping skills improve 2. Cohort effect (having/acquiring language for it) 3. Depressed people have died by old age - lol
71
Course of major depression
- Episodic | - Likely recurrent
72
Comorbidity of major depression
>70% and most frequent with: - Substance abuse - Anxiety disorder - Eating disorder
73
Dysthymia
Milder and more chronic than depression -Eore = poster child
74
Diagnostic criteria for Dysthymia
Depressed mood most of the day, every day for at least 2 yrs. While depressed, at least 2 of the following: - appetite disturbance - sleep disturbance - low energy/fatigue - low self esteem - poor concentration/indecisiveness - feelings of hopelessness
75
Lifetime prevalence of Dysthymia
- 6% | - Women>Men
76
Course of Dysthymia
- Chronic | - Fluctuation
77
Comorbidity of Dysthymia
>70%, with most frequent: - Substance abuse - Anxiety disorder - Eating disorder
78
Neurotransmitter theories of Major Depression & Bipolar disorder
- Monoamines - Dysfunction in synthesis - Brain abnormalities
79
Monoamines as related to Major Depression & Bipolar disorder
- Norepinephrine - Serotonin - Dopamine
80
Brain abnormalities as related to Major Depression & Bipolar disorder
Dysfunction in synthesis, release, & sensitivity of post synaptic neuron suggested - Prefrontal cortex - Anterior cingulate hippocampus - Amygdala
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Mood disorder
Involves several types of symptoms: affective, cognitive, physical/vegetative, and motivational - Major depression - Dysthymia - Bipolar disorder - Bipolar II disorder - Cyclothymia
82
Diagnostic criteria of major depressive episode
5+ of the following during 2 wk. period - Depressed mood most of the day, every day - Anhedonia - Significant change in appetite &/or weight - Sleep disturbance (hypersomnia or insomnia) - Psychomotor agitation or retardation - Fatigue/loss of energy - Feelings of worthlessness or inappropriate guilt - Decreased concentration or increased indecisiveness - Recurrent thoughts of death
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Anhedonia
Diminished interest or pleasure in all activities
84
Retardation wrt a major depressive episode
Slow talking / moving
85
Psychomotor agitation wrt a major depressive episode
Antsy / can't sit still
86
Double D
Dysthymia + Depressive episode
87
DEA Class I
High abuse potential; no accepted medical use -LSD, heroin
88
DEA Class II
High abuse potential with severe physical and psychological dependence -Amphetamines, opium, morphine, codeine, barbiturates, cocaine
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DEA Class III
Medium abuse potential with low to moderate physical dependence and high psychological dependence -Compounds containing codeine, narcotic analgesics, steroids
90
DEA Class IV
Low abuse potential with limited physical and psychological dependence -Benzodiazepines, certain barbiturates, other sedative-hypnotics, non-narcotic pain medicines
91
DEA Class V
Lowest abuse potential -Preparations with low narcotic levels
92
Premorbid = Prodromal factors in Schizophrenia
1. Parents/Blood relatives w/ Schizo 2. Prenatal issues - especially in 2nd trimester 3. Slowed RXN times or rapid recovery rate of ANS 4. Developmental &/or CNS dysfunction, hyperactivity 5. Low birth weight &/or low IQ relative to siblings 6. Early role as odd member of family or scapegoat 7. Parenting marked by inconsistency and by emotionally extreme responses and double messages 8. Rejection by peers 9. Early behavioral problems, especially noted in play and school (more irritable, unstable than others) 10. Inability to form stable, committed relationships
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Binge drinking
Consuming 5+ drinks within a couple of hours. | 4+ for women
94
Delirium tremens (DTs)
Stage 3 alcohol withdrawal symptom inculding auditory, visual and tactile hallucinations
95
Long term effects of alcohol use
- Low-grade hypertension -> ^risk of heart disease - Malnutrition - Alcohol-induced persisting amnesic disorder - Alcohol-induced dementia - CNS damage
96
Alcohol-induced persisting amnesic disorder
Permanent cognititve disorder caused by damage to CNS - Wernicke's encephalopathy - Korsakoff's syndrome
97
Wernicke's encephalopathy
Alcohol-induced persisting amnesic disorder Mental confusion and disorientation, and in severe states, coma
98
Korsakoff's syndrome
Alcohol-induced persisting amnesic disorder Memory loss for recent events and difficulty recalling distant ones
99
Alcohol-induced dementia
Loss of intellectual abilities, including memory, abstract thinking, judgment, and problem solving, often accompanied by personality changes such as increased paranoia - Seen in ~9% of chronic alcohol abusers or dependents - Common cause of adult dementia
100
Synergy
2+ parts acting together to be greater than sum of independent effects
101
Habituation
Diminishing of a physiological or emotional response to a frequently repeated stimulus
102
Tardive dyskinesia
Neurological disorder - Involuntary movements of tongue, face, mouth or jaw. - Involuntary lip smacking, sucking sounds, stick out toungue, puff their cheeks, or make other bizarre movements repeatadly -Reversible; may occur in 20%+ of long-term phenothiazine users
103
Akinesia
Side effect of Neuroleptic - Slowed motor activity - Monotonous speech - Expressionless face
104
Akathesis
Side effect of phenothiazine (Antipsychotic) Agitation that causes people to pace and be unable to sit still
105
Antipsychotic drugs
AKA Neuroleptics - Phenothiazines - Butyrophenones - Thioxanthenes
106
Chlorpromazine
Antipsychotic; Phenothiazine Calms agitation, reduces hallucinations and delusions in patients w/ Schizo
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What is the HPA axis
Hypothalamic Pituitary Adrenal Axis Hypothalamus>Pituitary>Adrenal - Fight or flight response - Early or chronic stress impacts HPA Axis, which may impact monoamine systems
108
What hormones are released HPA-Axis?
- CRH: Corticotropin releasing hormone | - ATCH: Adrenocorticotropic hormone
109
HPA Axis and depression
- Circuit stuck in the on position leads to depression | - High cortisol & CRH
110
Etiological theories of mood disorders
- Biological - Behavioral - Cognitive
111
Biological theory of mood disorder
Genetic factors - multiple genetic abnormalities strongly indicated - Seretonin transporter gene abnormalities
112
Behavioral theory of mood disorder
Decreased (+) reinforcers from stress or withdrawal; creates self-perpetuating cycles
113
Cognitive theory of mood disorder
Negative views of self, world & future (AKA negative triad) -perpetuated by distorted thinking
114
Reformulated Learned Helplessness Theory (RLHT)
Attibutions with negative events - Internal vs. external - Stable vs. unstable - Global vs. specifics Depressed people make internal, stable, global attributions
115
Interpersonal theories of mood disorders
- More likely to have chronic conflicts w/ family, friends, co-workers, etc. - RXN sensitivity + excessive reassurance seeking - May select less supportive circle
116
Bipolar disorder is aka
Manic depression
117
Bipolar disorder is characterized by
episodes of major depression and mania
118
Manic episode
At least 1 week of persistently elevated expansive or irritable mood, including >= 3 of the DSM criteria
119
Manic episode DSM criteria
- Decreased need for sleep (3-4 nights w/ only 1 hour of sleep) - Inflated self-esteem - Pressured speech - Racing thoughts - Distractibility - Increase in goal-oriented activity or psychomotor agitation - Excessive involvement in high-risk pleasurable activities
120
LIfetime prevalence of Bipolar disorder
1-2% | men=women
121
Comorbidity associated w/ Bipolar disorder
Anxiety, substance abuse, conduct disorders, gambling problems
122
Course of Bipolar disorder
Chronic, fluctuating, increased risk of suicide (7x)
123
Bipolar II disorder is characterized by
Episodes of major depression and hypomania
124
Hypomanic episode
Period of persistently elevated, expansive or irritable mood lasting at least 4 days and having symptoms of mania - same symptoms of mania & less severe - not psychotic like mania, not typically in trouble -Episode is NOT severe enough to cause marked impairment in functioning &/or hospitalization
125
Lifetime prevalence of Bipolar II disorder
1-2% | men=women
126
Course of Bipolar II disorder
Chronic, fluctuating, increased risk of suicide
127
Comorbidity of Bipolar II disorder
Substance abuse or dependence, anxiety disorders, & personality disorders
128
Depression:Dysthymia Bipolar:
Cyclothymia
129
Cyclothymia
>= 1 yr, episodes of hypomania & episodes of depressive symptoms that don't meet criteria for major depression - person is never free from symptoms for > 2 mo. at a time - like a sin curve wrt mania and depression
130
LIfetime prevalence of Cyclothymia
0.4-1% | men=women
131
Course of Cyclothymia
Chronic, 33% go on to develop Bipolar disorder
132
Comorbidity associated w/ Cyclothymia
- Panic disorder w/ agoraphobia - OCD - Alcohol abuse - Bulimia nervosa - Borderline & dependent personality disorder
133
Agoraphobia
Fear of leaving one's safe area (e.g. home)
134
Biological theories of Bipolar and Mood disorders
- First degree relatives have 5-10x rate of Bipolar & Mood disroder (vs. typical population) - MZ twins have 45-75x rate of Bipolar disorder than typical population
135
Neurotransmitter theories of Bipolar disorder
Dysregulation of dopamine system
136
Treatments for Major Depression and Dysthymia
- Psychotherapy | - Psychopharmacology
137
Psychotherapy for for Major Depression and Dysthymia
CBT = best established (i.e. walking dog) - Increase physical activity - Increase effective socialization - Increase pleasurable activities - Keep mood diary, ID thoughts, distortions, etc.
138
Psychopharmacology for Major Depression and Dysthymia
- Tricyclics & MAOIs (MonoamineOxidase inhibitors) - SSRIs - SNRIs
139
SSRIs
Selective serotonin reuptake inhibitors Fluoxetine - Sleep, appetite & energy are the first things to go up - suicidality > Black box warning - Moderately effective, but some risks - Very important to assess family history of Bipolar disorder before prescribing SSRIs - Bipolar will swing manic
140
Treatment for Bipolar, Bipolar II, & Cyclothymia
- Psychopharmacology | - Interpersonal & Social Rhythm Therapy
141
Psychopharmacology for Bipolar, Bipolar II, & Cyclothymia
- Mood stabalizers (Lithium) - Anti convulsants (e.g. Depakote, Tegretol, Lamital) - Atypical antipsychotics (e.g. Risperdel, Zyprexa, Seroquel, Abilify) *Biggest trick is compliance = getting patient to take their meds
142
Interpersonal & Social Rhythm Therapy for Bipolar, Bipolar II, & Cyclothymia
- Tracking & maintaining regularity of sleep, exercise & eating schedules - Develop coping strategies to decrease stress and emotional reactivity
143
Rapid cycling bipolar disorder
4+ cycles of mania & depression w/i 1 yr.
144
Which medications primarily treat (+) symptoms of Schizophrenia
Traditional anti-pscychotics
145
Which medications treat both (+) and (-) symptoms of Schizophrenia
Atypical anti-psychotics
146
What are some explanations for why major depression is more prevalent in more industrialized countries than in less industrialized ones
Need answer
147
Primary insomnia
Difficulty initiating or maintaining sleep, or nonrestorative sleep, for at least a month
148
Secondary insomnia
Cormorbid - secondary to another condition
149
Terminal insomnia
Waking up too early
150
Egoistic suicide
Committed by people who feel alienated from others, empty of social contacts, and alone in an unsupportive world
151
Anomic suicide
Committed by people who experience severe disorientation because of a major change in their relationship to society
152
Altruistic suicide
Committed by people who believe that taking their life with benefit society