Exam II-L9

Question 1

What receptor is affected in CF?

Answer 1

Mutation in CFTR (chloride channel)

Question 2

In CF, there is impaired chlorine transport, which leads to decreased secretion of ___ and increased uptake of ___ and ___

Answer 2

Less Cl secretion
More Na/water uptake

Question 3

Why do individuals with CF frequently get infections?

Answer 3

Accumulation of mucus in lungs

Question 4

Why do individuals with CF frequently have digestion and absorption problems?

Answer 4

Accumulation of mucus in pancreas causes blocked ducts (which deliver dig enzymes)

Question 5

Where is SGLT2 expressed?
Function?

Answer 5

Express in kidney
Responsible for glucose reabsorption in kidney

Question 6

SGLT inhibitors allow for excretion of excess ______ in the urine

Answer 6

blood glucose

Question 7

True or False: SGL2 Inhibitors aid in weight loss and decrease BP

Answer 7

True

Question 8

Where is dietary glucose absorbed? Via what transporter?

Answer 8

Intestine (SGLT1)

Question 9

SGLT inhibitors block ___ from being reabsorbed in the kidneys

Answer 9

blood glucose

Question 10

Which transporter facilitates the transfer of both glucose and sodium INTO the cell, with the energy of the sodium gradient

Answer 10

Symport SGLT 1

Question 11

True or False: Glucose moves along its concentration gradient in the intestine, via Symport SGLT1

Answer 11

False - Glucose must move AGAINST its concentration gradient in the intestine, via SGLT1

Question 12

Na/K Pump and GLUT 1 are examples of

Answer 12

Symporters/SGLT1

Question 13

Does Symporter SGLT1 require ATP? Where does it find energy?

Answer 13

No
- Uses the energy of the sodium gradient

Question 14

In SGLT1, Na/glucose are co-transported across apical membrane via SGLT. Excess sodium that has entered the cell is pumped out via: ____

Answer 14

NaK ATPase

Question 15

In the presence of SGLT1, glucose is transported from the epithelial cell into the blood via a ______ on the basolateral membrane

Answer 15

glucose uniporter

Question 16

What happens if SGLT1 is inhibited?

Answer 16

Diarrhea

Question 17

What transporter does pancreas use to absorb glucose?

Answer 17

GLUT2

Question 18

In DM, glucose increases and travels to brain, liver, pancreas, and GLUT1-3. Following this, pancreas absorbs glucose but no ___ is release. Therefore: glucose is not transported into muscle/tissue via ___

Answer 18

insulin; GLUT4

Question 19

True or False: In patients with DM, kidneys excrete excess glucose into urine to reduce blood glucose levels, leads to glucosuria

Answer 19

True

Question 20

What transporter does insulin use to transport glucose into muscle and adipose?

Answer 20

GLUT4

Question 21

Which uniport facilitates transport of glucose into the cell, in favor of its concentration gradient?

Answer 21

GLUT4

Question 22

What does glucose transport require to work?

Answer 22

Glucose gradient

Question 23

Does GLUT4 require ATP?
If no, what does it require?

Answer 23

No
- Requires insulin to reach the cell membrane

Question 24

True or False: Binding of insulin to its receptors promotes recruitment of glucose transporters from intracellular pool to cell membrane

Answer 24

True

Question 25

Does glucose transport require ATP?

Answer 25

No

Question 26

Where are glucose uniporters located?

Answer 26

muscle and fat

Question 27

Do Antiporters require energy? ATP?

Answer 27

Antiporters require energy, but NOT ATP

Question 28

____: use energy generated during transport of a molecule along its concentration gradient to transport a second molecule against its concentration gradient - both move in opposite directions

Answer 28

Antiporters

Question 29

Sodium/Calcium move via ____

Answer 29

anitporter

Question 30

True or False: Symporters require ATP, but not energy

Answer 30

False - symporters do NOT require ATP but do require energy

Question 31

____: uses energy made during transport of a molecule along its concentration gradient to transport a second molecule against its concentration gradient - both move in same directions

Question 32

Example of a symporter?

Answer 32

SGLT

Question 33

Do symporters require ATP? energy?

Answer 33

Symporters require energy - not ATP

Question 34

Symporters and Antiporters are examples of ____ P, V and F, and ABC Pumps are examples of

Answer 34

secondary active transport primary active transport

Question 35

Secondary active transport requires ___ but not ___

Answer 35

energy; ATP

Question 36

What type of transporter can pump out drugs and make a cancer cell resistant to this drug by limiting amount of drug that gets into the cell?

Answer 36

ABCB1 Pump (also known as MDR)