Exam One Flashcards
(220 cards)
What does the endocrine system use to regulate the body?
Chemicals (hormones)
What are the basic functions of the endocrine system?
Maintaining homeostasis
Responds to stress
Growth and development
Sexual reproduction
How does the nervous system regulate the body?
Electrical impulses
What are endocrine glands?
Glands that secrete only hormones
Release hormones directly into the bloodstream
What are exocrine glands?
Glands that secrete sweat and oils
Produce secretions into a duct or outside the body
What are neurocrine glands?
Nervous tissues that produce a hormone
Hypothalamus
What are autocrines?
Hormones released locally into interstitial fluid and affect same type of cell they were released from
What are paracrines?
Hormones released locally and affects neighboring cells of different type
What are the true endocrine glands?
Pineal Anterior pituitary Thyroid Parathyroid Adrenal
What are the multiple function endocrine glands?
Hypothalamus Posterior pituitary Thymus Pancreas Ovaries Testes
What are the four classes of hormones?
Steroids
Proteins
Amino acids
Prostonoids
What is the process that must occur for steroids to be transported?
Bind to carrier protein
Pass through plasma membrane of cell
Bind to receptor inside the cell
Causes direct interaction on the cell
What are the four ways that steroids can be transported?
Cortisol - Cortisol Binding Globulin - Strong affinity
Testosterone/Estrodiol - TEBG - Strong affinity
Albumin - can bind to testosterone and estrodiol with weak affinity
Free hormone - circulates through blood alone
What are biologically active hormones?
Hormones that are able to be used right now
Free hormone and albumin
What are biologically inactive hormones?
Hormones that are unable to be used right now
TEBG and CBG
What is the mechanism of action for steroids?
- Steroid hormone diffuses through the plasma membrane and binds to an intracellular receptor
- Receptor-hormone complex enters the nucleus
- Receptor-hormone complex binds a specific DNA region
- Binding initiates transcription of the gene to mRNA
- The mRNA directs protein synthesis
What is the mechanism of action for amino acids?
- Hormone (first messenger) binds to receptor
- Receptor activates G protein
- G protein activates adenylate cyclase
- Adenylate cyclase converts ATP to cAMP (2nd messenger)
- cAMP activates protein kinases
How are hormones removed from blood?
Degrading enzymes
kidneys
liver
What is basal secretion?
General day to day hormone secretion
What is stimulatory secretion?
Secretion requires a stimulus
What is pulsatile stimulation?
Basal secretion when there are peaks throughout the day
What are the three types of endocrine gland stimulation?
Humoral
Neural
Hormonal
What is humoral stimulation?
Changing blood levels of ions and nutrients directly stimulate secretion
Calcium levels and parathyroid
What is neural stimulation?
Nerve fibers stimulate hormone release