EXAM2 L4

Question 1

Degree of ionization is

Answer 1

pH dependent

Question 2

Small change in pH can cause a large change in

Answer 2

Ratio of ionized to unionized (affects solubility, dissolution rate and partition coefficient, in turn affecting absorption, distribution and elimination

Question 3

Common acidic functional groups in drugs

Answer 3

Aliphatic carboxylic acid
Sulfonic acid
Thiol
Aromatic carbox. acid
Phenols
Imide

Question 4

Common Basic Functional Groups in Drugs

Answer 4

Primary amine
Imidazoles
Anilines
Secondary amine
Tertiary amine
Pyridines

Question 5

Non-ionizable functional groups in drugs

Answer 5

Alcohols
Aldehydes
Amides
Esters
Ketones
Ethers

Question 6

Lowry-Bronsted concept

Answer 6

Acid is a proton donor, base is a proton acceptor

Question 7

Ka is

Answer 7

The acidity, or the dissociation constant

Question 8

Ionization profile of a weak acid/ v.s. weak base

Answer 8

pKa = pH where 50% of compound is ionized (Acid - curve goes up; Base - curve goes down)

Question 9

The solubility of weak electrolytes is strongly dependent on

Answer 9

pH

Question 10

Many drugs are…

Answer 10

Weakly electrolytes

Question 11

T/F: Ionized form of the drug is more soluble than unionized form

Answer 11

True

Question 12

T/F: Alternation of pH is common method to solubilize drugs

Answer 12

True

Question 13

Physiological pH range is…

Answer 13

1-8.5

Question 14

At any pH, the solubility is the sum of the concentration of the

Answer 14

Ionized and unionized forms