Lecture 5 Flashcards
what are come common excipients
celllose, sucrose, starch, and synthetic polymers lik PVP
what are some critical factors in excipient selection
source, quality, purity, consistency, stability, cost compatibility
what affects bioavailability and stability
disintegrates, coatings, flavors. colors
what are the organoleptic senses when coating
sight, smell, sound, taste, touch
T/F dosage forms need to have uniformity
True
how much API is usually in a tablet
85-115%
how long should a drug be shelf stable
2 years
what does friable mean
can break into smaller pieces
T/F should dosage forms be friable
false
why are coatings used
to control diffusion rate
why are disintegrates used
to control regions of release based on physicochemical properties
what are lubricants used
to slow dissolution based on propeties
aqueous film coatings generally contain what
film-forming polymer, plasticizer, colorant, vehicle
what are enteric coatings
coatings to prevent the early release of an API in a region where it may undergo chemical or metabolic breakdown
why are enteric coatings used
prevent Gi distress, get to the target, provide delayed release, deliver API in high concentration to intestines
