lecture 4

Question 1

what does formulation design require

Answer 1

physicochemical properties of drug and composition of formulation and biological factors that influence performance

Question 2

what does ADMET mean

Answer 2

absorption, distribution, metabolism, excretion, toxicity

Question 3

what factors govern the drug performance in the clinic

Answer 3

the physiochemical properties of the API and the composition of the formulation, the physiological barriers that influence the targeted bioavailability of the drug

Question 4

what are some physiological properties that affect absorption

Answer 4

solubility, stability, lipophilicity, molecular size and shape, pKa of the ionizable groups and physical state of the drug

Question 5

what does solubility depend on

Answer 5

molecular structure, physical state, composition of solvents, measurement methods

Question 6

T/F different extracellular and intracellular pHs can affect drug transport

Answer 6

true

Question 7

T/F organelle pH can result in the trapping of a molecule in a cell as well

Answer 7

True

Question 8

how to overcome the effects of the pH

Answer 8

change pKa, prodrug strategy, salt selection, and drug delivery system

Question 9

what are prodrug startegies

Answer 9

modifying the charge and the molecule to be recognized by a transporter

Question 10

what are exipients

Answer 10

inert ingredients added to active compounds to improve appearance, bioavailability, stability and palatability

Question 11

T/F excipients are inert

Answer 11

false they are not inert