Exocrine pancreas

Question 1

Serum amylase

Answer 1

Not specific to pancreas (does have a higher concentration though)
Seen in Intestine, Salivary gland (except dogs), ovary and testes

Question 2

Amylase

Answer 2

Hydrolyzes complex carbs to form maltose and glucose

Question 3

Increased serum amylase

Answer 3

-Acute pancreatitis and neoplasia
-Chronic renal insufficiency
-Decreased GFR
-Intestinal disease of obstruction
(rare in cats)

Question 4

Lipase

Answer 4

Hydrolyzes triglycerides

Question 5

Serum lipase

Answer 5

Several forms:
-Pancreatic
-Hepatic
-Gastrointestinal
-Renal
-Lipoprotein

Question 6

Increased serum lipase

Answer 6

-Acute pancreatitis
-Pancreatic neoplasia
-Gastrointestinal disease
-Hepatic disease
-Azotemia
-Hyperadrenocorticism

Question 7

Mild increased in amylase and lipase

Answer 7

Usually due to GFR (2-3x UPR)

Question 8

moderate increase in amylase and lipase (>3-5x URI)

Answer 8

Pancreatic disorder

Question 9

Increase in proteolytic enzymes

Answer 9

-Acinar cell damage
-Decreased renal excretion
-Recent food consumption
-Cats: vitamin B12 deficiency

Question 10

Decrease in proteolytic enzymes

Answer 10

-Reduced secretion from acinar cells
-Chronic pancreatitis
-Exocrine pancreas insufficiency

Question 11

Serum pancreatic lipase immunoreactivity

Answer 11

Uses antibody specific for pancreatic lipase
Good for ruling in pancreatitis if + but not useful for ruling it out if negative

Question 12

Exocrine pancreatic insufficiency

Answer 12

Inadequate pancreatic enzymes diagnose with serum trypsin-like immunoreactivity

Question 13

Serum trypsin-like immunoreactivity

Answer 13

Uses antibodies against both trypsin and trypsinogen which is only synthesized by pancreas and is species specific