Coagulation Disorders

Question 1

Coagulopathy type bleed

Answer 1

Delayed deep tissue hemorrhage, hematomas, hemorrhage into body cavities. Usually more life threatening

Question 2

Prekallikrein deficiency

Answer 2

Autosomal recessive. Not usually associated with clinical bleeding. Increased APTT and ACT. Seen in horses and dogs

Question 3

Factor XII deficiency

Answer 3

No clinical bleeding and autosomal inheritance
Increased APTT and ACT

Question 4

Factor VII Deficiency

Answer 4

Mild to no clinical bleeding, autosomal inheritance
Increased PT

Question 5

Factor VIII deficiency

Answer 5

Hemophilia A, X linked inheritance
Mild to severe bleeding
Increased APTT and ACT

Question 6

Factor IX Deficiency

Answer 6

Hemophilia B, X linked
Mild to severe bleeding
Increased APTT and ACT

Question 7

Vitamin K deficiency causes

Answer 7

Dietary inadequacy
Biliary obstruction
Malabsorption
Liver disease
Drugs

Question 8

Vitamin K antagonism

Answer 8

-Coumarin
-Warfarin
-Sweet clover hay

Question 9

Warfarin

Answer 9

Inhibits epoxide reductase and prevents Vitamin K recycling that is used to create negatively charged coagulation proteins. Affects VII first because of the shorter half life

Question 10

Secondary problem with long term Vitamin K treatment

Answer 10

Heinz body formation and subsequent hemolysis

Question 11

Decompensated DIC findings

Answer 11

Prolonged APTT and PT
Thrombocytopenia
Decreased fibrinogen (dogs and cats)
Normal or increased fibrinogen (cattle and horses
Increased FDPS and D-dimers