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QUIZ 15 > extra > Flashcards

extra Flashcards

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1
Q

effector memory T cell markers

A

CD45RO; no CCR7 or L-selectin

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2
Q

central memory T cell markers

A

CD45RO, CCR7, L-selectin, and CD44

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3
Q

naive T cell markers

A

CD45RA, CCR7, L-selectin

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4
Q

myeloid cell markers

A

no CCR7 or L-selectin

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5
Q

CD8+ cells

A

kill virus-infected cells

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6
Q

CD4+ Th1 cells

A

activate infected macrophages and help B cells; for listeria or mycobacteria

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7
Q

CD4+ Th2 cells

A

switch B cells to IgE by releasing IL-4; for parasites

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8
Q

CD4+ Th17 cells

A

recruit neutrophils and barrier integrity; for fungi and pneumonia

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9
Q

CD4+ Tfh cells

A

antibody production

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10
Q

CD4+ Treg cells

A

suppress T cells

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11
Q

CD45RA

A

naive T cells

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12
Q

CD45RO

A

memory marker

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13
Q

ICAM-1,2,3

A

on endothelial cells; binds LFA-1 and Mac-1 for adhesion

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14
Q

VCAM-1

A

on endothelial cells; binds VLA-4 for adhesion

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15
Q

L-selectin

A

on naive T cells and promotes migration into HEVs by binding PNAds

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16
Q

PNAds

A

GlyCAM-1, CD34 for slow rolling

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17
Q

P & E-selectins

A

on non-lymphoid tissue (bind core-2 glycans)

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18
Q

CCR9

A

gut specific T cell chemokine receptor

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19
Q

CCR7

A

T cell chemokine receptor

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20
Q

CCL19/CCL21

A

chemokines that bind CCR7

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21
Q

MadCAM-1/a4b7

A

bind L-selectin in gut

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22
Q

CXCR4/CXCL12

A

diapedesis

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23
Q

IL-1

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A

most potent, part of acute phase response and lymphocyte activating factor; released by macrophages

24
Q

IL-3

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A

maintains stem cells and progenitors and induces proliferation; released by Th1 and Th2 cells

25
IL-4
makes Th2 for IgE production; released by basophils
26
IL-5
eosinophil generation; IgA class switch
27
IL-6
metabolism, heat generation; makes Th17 and Tfh
28
IL-7
induces lymphoid lineage
29
IL-8
attracts neutrophils; angiogenic factor
30
IL-10
resolution
31
IL-12
enhances production of IFN-gamma by NK cells and T cells; Th1 induction
32
IL-15
makes NK cells
33
IL-17
recruits PMNs
34
IL-23
stimulate Th17
35
IL-21
stimulate Th17; cell proliferation
36
TNF-alpha
vessel permeability
37
type I IFN
antiviral
38
TGF-beta
makes Treg
39
innate response to virus
virus --> NK cells/pDCs --> type I IFN --> DCs --> CD8+ --> IFN-gamma --> IgG
40
innate response to IC bacteria
macrophages --> IL-12 --> DCs --> Th1 --> IFN-gamma --> IgG
41
innate response to EC bacteria/fungi
macrophages/neutrophils --> IL-23 --> DCs --> Th17 --> IL-17 --> IgG/IgA
42
innate response to parasites
eosinophils/basophils --> IL-4 --> DCs --> Th2 --> IL-4 --> IgE
43
type I hypersensitivity
IgE-mediated response to allergies
44
type II hypersensitivity
IgM or IgG-mediated response to self-antigens
45
type III hypersensitivity
IgG-mediated response to antigen-antibody complex (serum sickness)
46
type IV hypersensitivity
cell-mediated dermatitis from Th1 macrophage activation
47
CD4 releases _ for Th1 stimulation
IL-12
48
CD4 releases _ for Th2 stimulation
IL-4
49
CD4 releases _ for Th17 stimulation
IL-1, IL-6, IL-21
50
CD4 releases _ for Treg stimulation
TGF-beta
51
CD4 releases _ for Tfh stimulation
IL-6, IL-21
52
Th1 releases _
IFN-gamma
53
Th2 releases _
IL-4
54
Th17 releases _
IL-17
55
Treg releases _
TGF-beta
56
Tfh releases _
IL-21

QUIZ 15 (16 decks)

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