extra

Question 1

what makes subsequent steps more thermodynamically favourable

Answer 1

making malonyl coa

Question 2

what in ACP is useful

Answer 2

vitamin B5 derivative that contains SH group

Question 3

where do we get DHAP for TAG synth

Answer 3

glycolysis
gluconeogenesis
glyceroneogenesis

Question 4

glycerol kinase is where

Answer 4

liver and kideny

Question 5

removal of phosphate gorup on phosphatidic acid

Answer 5

phoasphatidci acid phosphotase

Question 6

precursor of TAG

Answer 6

phosphotidic acid

Question 7

what does phosphotidic acid phosphotase yield

Answer 7

1,2 diacylglycerol

Question 8

what cells dont have glycerol kinase

Answer 8

adipose cells

Question 9

where does glyceroneogenesis occur

Answer 9

liver and adipose tissue

Question 10

head groups of phospholipids

Answer 10

serine, H, choline, ethanolamine, inisitol, glycerol

Question 11

what functions to store FA, and signallnig molecules iwthin cells

Answer 11

phospholipids

Question 12

what do VLDLs do

Answer 12

deliver TAG from liver to non hepatic tissue

Question 13

what does LDL do

Answer 13

delivers cholesterol AND CHOLESTEROL ESTERS from liver to non hepatic tissue

Question 14

functions for cholesterol transport/ clearance

Answer 14

apoB48

Question 15

binds to LDL receptors

Answer 15

APOB100

Question 16

where is apo B48 generated

Answer 16

in the intestine

Question 17

what is fromed by A1 or A2

Answer 17

lysophospholipid

Question 18

what is removed by A2 in mammals

Answer 18

arachidonic acid (20:4n-6) form sn2

Question 19

what cells express LDL receptors

Answer 19

adipose and muscle

Question 20

what happens to cholesterol from HDL in liver

Answer 20

metabolized

Question 21

where is LPL

Answer 21

anchored to cell surfaces of tissues exxposed to circulation

Question 22

what does LPL do

Answer 22

hydrolyzes triglycerides containing 48 and 100

Question 23

genetic disorders

Answer 23

LPL deficiency
LDL receptor defect

Question 24

RCT ulitimate action

Answer 24

ultimately for excretion from the body

Question 25

cholesterol efflux

Answer 25

transfer of cholesterol and phospholipids to nascnet HDL

Question 26

cholesterol ester to cholesterol enzyme

Answer 26

CHOLESTEROL ESTER HYDROLASE

Question 27

what do omega 3 FA do

Answer 27

inc cholesterol efflulx reduce sdLDL!!!!!!!!!!!!!!

Question 28

where do bile acids work

Answer 28

in the interstine

Question 29

bile salts

Answer 29

conjugated bile acids such as taurine and glycine

Question 30

where are bile acids formed and stored

Answer 30

formed in liver and stored in galbladder

Question 31

what increases excretion fo bile acids

Answer 31

bile acid binding agents

Question 32

multifactorila features of atheroschlerosis

Answer 32

lipid disorder hypertensive disorder inflamatory disorder

Question 33

what is atheroschlerosis

Answer 33

excess deposition of lipids (TAG and cholesterol) in macrophages in arterial walls

Question 34

what are monocytes attracted to

Answer 34

oxidized liporoteins that aggregate and stick to extracellular matrix

Question 35

what happesn after foam celll ingests lipoprotein

Answer 35

free C accumulate in membranes and droplets cholesterol rich plaques form

Question 36

what causes formation of sdLDL

Answer 36

high LDL excress hydrolysis

Question 37

oxLDL

Answer 37

LDL protein AND lipid are oxidized

Question 38

what down regulates cholesterol synth

Answer 38

PUFA

Question 39

do PUFAs do

Answer 39

down regular cholesterol synth inhibit CETP riase HDL