extra bits Flashcards
(36 cards)
mitochorndial inheritenace
mums
glycolysis
glucose to pyrivate (bisphosphae)
glycogenolysis
breakdown of glycogen to glucsoe
medenlan peretrance
high
15
angel man
ras
GTP binding
BRAF
melanoma
myc
nuclear transcription factoro promoting DNA replicaiton eg lung carcinoma
what does b12 do
stops apoptosis
ec50
the conc on the agonist which results in a half maxmimal response ie 50% of the receptors are occupied
ed50
dose at which 50% of receptors are occupied
what determines potency
ec50
which drugs can move readily by diffusion
unionised drugs
what is the equation for vd volume
dose (mass) / plasma concentration
what is the threshold for a sad TR
> 10
equation for half life
t1/2 = 0.69/kel
rate of elimination
clearnace x plasma conc
ADME (factors which influence drug disposition)
abdoption, distibution, metabolism, excretion
renal excretion of drugs and drug metabolites
- glomerular filtration = (only unbound)
- active tubular secretio
- passive reabostopion across tubular epithelium
cadherins
hold cells within tissues together
integrins
span membrance acting as lingk between extra and intra cellular environments
hypertonic
water flows out of cell
hypotonic
water flows into cell
example of neg feedback
maintaing core temperature
